Synergistic Hair Growth Effect of Combined Minoxidil and Rosemary Oil Nanoemulsion-Loaded In Situ Gels

    Rania Hamed, Islam Taha Hlalat, Osama H. Abusara, Nour Aboalhaija, Suhair Hikmat, Aya Hasan, Sameer Al-Kouz
    TLDR Combining minoxidil and rosemary oil in a gel promotes better hair growth than using them separately.
    The study successfully developed minoxidil (MIN), rosemary oil (RO), and a combination of MIN-RO nanoemulsions (NEs) and their corresponding in situ gels to treat alopecia and promote hair growth. The selected formulations exhibited spherical droplets and were thermodynamically stable, showing no phase separation or degradation after various stability tests. The combination of MIN and RO in a nanoemulsion-loaded in situ gel demonstrated a synergistic effect, enhancing skin permeability and promoting hair growth more effectively than individual components. This novel delivery system offers improved patient compliance and prolonged skin contact, potentially providing a more effective treatment for alopecia.
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