Co-Delivery of Minoxidil and Finasteride via Ionic Liquid and Cyclodextrin-Assisted In Situ Thermosensitive Hydrogel for Synergistic Treatment of Androgenic Alopecia

    January 2025 in “ International Journal of Pharmaceutics ”
    Ziyi Liu, Xiaojuan Li, Sha Xiong … Yuehong Xu
    Studysummary A new gel improves hair loss treatment by effectively delivering minoxidil and finasteride to the scalp.
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    Research cited in this study 29

    1. Active Pharmaceutical Ingredient-Ionic Liquids Assisted Follicular Co-Delivery of Ferulic Acid and Finasteride for Enhancing Targeted Anti-Alopecia International Journal of Pharmaceutics · 2023
    2. Thermodynamically Stable Ionic Liquid Microemulsions for Topical Delivery and Peptide Application Bioactive materials · 2023
    3. Efficacy of Topical Minoxidil and Finasteride Association Compared to Monotherapy in Men With Androgenetic Alopecia: A Prospective, Randomized, Controlled, Assessor-Blinded, 3-Arm, Pilot Trial Journal of Cosmetic Dermatology · 2023
    4. Treatment of Androgenetic Alopecia: Current Guidance and Unmet Needs Clinical, Cosmetic and Investigational Dermatology · 2023
    5. Comparative Efficacy of Topical Finasteride (0.25%) in Combination With Minoxidil (5%) Against 5% Minoxidil or 0.25% Finasteride Alone in Male Androgenetic Alopecia: A Pilot, Randomized Open-Label Study International Journal of Trichology · 2023
    6. Dual-Mode Vasodilator M119 Delivery to Hair Follicle via Dissolving Microneedle for Advanced Alopecia Treatment Advanced therapeutics · 2022
    7. Ceria Nanozyme-Integrated Microneedles Reshape the Perifollicular Microenvironment for Androgenetic Alopecia Treatment ACS Nano · 2021
    8. KY19382, A Novel Activator of Wnt/β-Catenin Signalling, Promotes Hair Regrowth and Hair Follicle Neogenesis British Journal of Pharmacology · 2021
    9. Pattern Hair Loss: Assessment of Microinflammation in Miniaturized and Terminal Hair Follicles Through Horizontal Histologic Sections Journal of The American Academy of Dermatology · 2020
    10. Co-Loading of Finasteride and Baicalin in Phospholipid Vesicles Tailored for the Treatment of Hair Disorders Nanoscale · 2020
    11. Transdermal Finasteride Delivery via Powder-Carrying Microneedles with a Diffusion Enhancer to Treat Androgenetic Alopecia Journal of Controlled Release · 2019
    12. Minoxidil And Its Use In Hair Disorders: A Review Drug Design Development and Therapy · 2019
    13. Beta-Catenin-Mediated Hair Growth Induction Effect of 3,4,5-Tri-O-Caffeoylquinic Acid Aging · 2019
    14. A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2018
    15. Alginate-Based Hydrogel Containing Minoxidil/Hydroxypropyl-β-Cyclodextrin Inclusion Complex for Topical Alopecia Treatment Journal of Pharmaceutical Sciences · 2017
    16. Experimental, Molecular Docking Investigations and Bioavailability Study on the Inclusion Complexes of Finasteride and Cyclodextrins Drug Design Development and Therapy · 2017
    17. Androgenetic Alopecia: A Review Endocrine · 2017
    18. Safety Profile of Finasteride: Distribution of Adverse Effects According to Structural and Informational Dichotomies of the Mind/Brain Clinical Drug Investigation · 2017
    19. Androgenetic Alopecia: An Update Of Treatment Options Drugs · 2016
    20. Minoxidil Topical Treatment May Be More Efficient If Applied on Damp Scalp Compared to Dry Scalp Dermatologic Therapy · 2016
    21. Apoptosis in Follicles of Individuals with Female Pattern Hair Loss Is Associated with Perifollicular Microinflammation International Journal of Cosmetic Science · 2016
    22. Effects of a Novel Finasteride 0.25% Topical Solution on Scalp and Serum Dihydrotestosterone in Healthy Men with Androgenetic Alopecia International Journal of Clinical Pharmacology and Therapeutics · 2015
    23. A Novel Finasteride 0.25% Topical Solution for Androgenetic Alopecia: Pharmacokinetics and Effects on Plasma Androgen Levels in Healthy Male Volunteers International Journal of Clinical Pharmacology and Therapeutics · 2014
    24. VEGF Induces Proliferation of Human Hair Follicle Dermal Papilla Cells Through VEGFR-2-Mediated Activation of ERK Experimental Cell Research · 2012
    25. Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice Journal of Investigative Dermatology · 2011
    26. Hair Growth and Rejuvenation: An Overview Journal of Dermatological Treatment · 2010
    27. Molecular Mechanisms Regulating Hair Follicle Development ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2002
    28. Allergic Contact Dermatitis to Topical Minoxidil Solution: Etiology and Treatment Journal of The American Academy of Dermatology · 2002
    29. Teloptosis: A Turning Point in Hair Shedding Biorhythms Dermatology · 2001

    Related research 9

    1. Oral Finasteride (5 mg and 2 mg) Versus Topical Minoxidil 5% in Female Pattern Hair Loss Clinical Dermatology Review · 2025
    2. Comparative Study of Topical Minoxidil (5%) Plus Finasteride (0.1%) Versus Platelet-Rich Plasma Plus Topical Minoxidil (5%) Plus Finasteride (0.1%) in Patients with Androgenic Alopecia Asian Journal of Pharmaceutical and Clinical Research · 2024
    3. Controversies in the Treatment of Androgenetic Alopecia: The History of Finasteride Dermatologic Therapy · 2018
    4. A Randomized, Double-Blind Controlled Study of the Efficacy and Safety of Topical Solution of 0.25% Finasteride Admixed with 3% Minoxidil vs. 3% Minoxidil Solution in the Treatment of Male Androgenetic Alopecia Journal of The European Academy of Dermatology and Venereology · 2018
    5. Efficacy of Non-Surgical Treatments for Androgenetic Alopecia: A Systematic Review and Network Meta-Analysis Journal of The European Academy of Dermatology and Venereology · 2018
    6. The Modern Treatment of Androgenetic Alopecia Vestnik dermatologii i venerologii · 2017
    7. Topical Minoxidil Fortified with Finasteride: Maintenance of Hair Density After Replacing Oral Finasteride International journal of scientific research · 2016
    8. Combined Treatment with Oral Finasteride and Topical Minoxidil in Male Androgenetic Alopecia: A Randomized and Comparative Study in Chinese Patients Dermatologic Therapy · 2015
    9. A New Topical Formulation of Minoxidil and Finasteride Improves Hair Growth in Men with Androgenetic Alopecia Journal of clinical & experimental dermatology research · 2015