Co-Delivery of Minoxidil and Finasteride via Ionic Liquid and Cyclodextrin-Assisted In Situ Thermosensitive Hydrogel for Synergistic Treatment of Androgenic Alopecia

    January 2025 in “ International Journal of Pharmaceutics ”
    Ziyi Liu, Xiaojuan Li, Sha Xiong, Ting Xiao, Siwen Jiao, Guihong Chai, Yuehong Xu
    TLDR A new gel improves hair loss treatment by effectively delivering minoxidil and finasteride to the scalp.
    The study developed a novel in situ thermosensitive hydrogel combining ionic liquid, cyclodextrin, and poloxamer for the co-delivery of minoxidil (MXD) and finasteride (FIN) to hair follicles, aiming to treat androgenic alopecia (AGA) synergistically. This hydrogel, termed M+F@ICPG, transitions from liquid to gel upon contact with the scalp, enhancing drug retention in the skin and reducing systemic toxicity. The formulation improves the solubility and targeted delivery of MXD and FIN, overcoming the stratum corneum barrier and providing synergistic effects by promoting angiogenesis, inhibiting 5α-reductase 2, and reducing inflammation. The efficacy of M+F@ICPG was demonstrated in a testosterone-induced AGA mouse model, suggesting it as a promising strategy for AGA treatment.
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      community Why can’t we just do another creatine study?

      in Chat  153 upvotes 11 months ago
      Creatine may worsen hair loss in some, especially with androgenic alopecia, but evidence is mixed. Some users experience no hair loss when using creatine with minoxidil and finasteride, while others notice increased shedding.

      community Stopped minoxidil for a year after a year of using it. Starting again.

      in Minoxidil  158 upvotes 3 years ago
      ? This post by PastelDeUva discusses their experience with Minoxidil and Finasteride for hair loss treatments, which they stopped using for a year before resuming due to family's negative opinion. After restarting, they posted photos of the progression/regression of their hairline and are now planning on adding finasteride and dermarolling in order to get good results.

      community Shopping receipts are anti-androgenic?

      in Chat  29 upvotes 1 year ago
      The conversation discusses the potential use of thermal paper receipts, which contain estrogen, as a treatment for hair loss. Participants humorously debate its effectiveness compared to established treatments like Minoxidil and finasteride.

      community 15 years of finasteride/minoxidil

      in Update  194 upvotes 1 year ago
      A user shared a 15-year experience using minoxidil and finasteride for hair loss, stating that despite never missing a dose, their hairline continued to recede slowly. Other users suggested that the hair loss might be exacerbated by the use of steroids and recommended considering other treatments like dutasteride and RU58841.

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