Safety Profile of Finasteride: Distribution of Adverse Effects According to Structural and Informational Dichotomies of the Mind/Brain

February 2017 in “ Clinical Drug Investigation ”

Ion G. Motofei, David L. Rowland, Mirela Manea, Simona Roxana Georgescu, Ioana Paunica, Ioanel Sinescu

finasteride male pattern baldness sexual dysfunction depression post-finasteride syndrome dihydrotestosterone dihydroprogesterone Propecia DHT

Studysummary This paper discusses the adverse effects of finasteride, including sexual dysfunction and depression, and suggests that treatment customization based on individual factors like hand preference and sexual orientation could improve outcomes and reduce these side effects.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

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research Atypical Post-Finasteride Syndrome: A Pharmacological Riddle

8 citations , May 2016 in “Indian Journal of Pharmacology”

This case report describes an atypical postfinasteride syndrome in a patient treated with both dutasteride and finasteride for androgenic alopecia, highlighting its multisystem involvement and irreversible nature.

Finasteride Adverse Effects in Subjects with Androgenic Alopecia: A Possible Therapeutic Approach According to the Lateralization Process of the Brain

research Finasteride Adverse Effects in Subjects with Androgenic Alopecia: A Possible Therapeutic Approach According to the Lateralization Process of the Brain

21 citations , April 2016 in “Journal of Dermatological Treatment”

This paper discusses the potential relationship between finasteride's adverse effects and factors like hand preference and sexual orientation, suggesting these could influence risk in male androgenic alopecia treatment, but reports no new clinical results.

Are Hand Preference And Sexual Orientation Possible Predicting Factors For Finasteride Adverse Effects In Male Androgenic Alopecia?

research Are Hand Preference And Sexual Orientation Possible Predicting Factors For Finasteride Adverse Effects In Male Androgenic Alopecia?

12 citations , March 2016 in “Experimental Dermatology”

This review discusses the potential for hand preference and sexual orientation to predict sexual side effects of finasteride in men with androgenic alopecia, but reports no new clinical results.

An Observational Retrospective Evaluation of 79 Young Men with Long-Term Adverse Effects After Use of Finasteride Against Androgenetic Alopecia

research An Observational Retrospective Evaluation of 79 Young Men with Long-Term Adverse Effects After Use of Finasteride Against Androgenetic Alopecia

43 citations , January 2016 in “International Journal of Andrology”

This study found that men experiencing long-term symptoms after finasteride use for androgenetic alopecia frequently reported loss of penis sensitivity and anhedonia, among other effects, indicating potential post-finasteride syndrome.

research Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study

69 citations , July 2015 in “Pharmacotherapy”

This study found that low-dose finasteride use in young men was associated with higher reporting of persistent sexual dysfunction, with some cases linked to suicidal ideation.

research Safety Concerns Regarding 5α Reductase Inhibitors for the Treatment of Androgenetic Alopecia

33 citations , April 2015 in “Current Opinion in Endocrinology, Diabetes and Obesity”

This review discusses the potential persistent adverse effects associated with 5α reductase inhibitor treatment for androgenetic alopecia but provides no new clinical results; it emphasizes the importance of discussing these risks with patients.

research Androgenetic Alopecia: An Evidence-Based Treatment Update

151 citations , May 2014 in “American Journal of Clinical Dermatology”

This review concluded that oral finasteride for men and topical minoxidil for both genders have the most evidence supporting their effectiveness and safety for treating androgenetic alopecia.

Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation

research Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation

61 citations , April 2014 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study reports that men with androgenic alopecia experience altered neuroactive steroid levels associated with persistent depression symptoms even after stopping finasteride treatment.

research Decreased Alcohol Consumption Among Former Male Users of Finasteride with Persistent Sexual Side Effects: A Preliminary Report

27 citations , June 2013 in “Alcoholism: Clinical and Experimental Research”

In this study, 65% of men with persistent sexual side effects after stopping finasteride reported a reduction in alcohol consumption, echoing findings in rodent models.

A Pilot Study on the Sexual Side Effects of Finasteride as Related to Hand Preference for Men Undergoing Treatment of Male Pattern Baldness

research A Pilot Study on the Sexual Side Effects of Finasteride as Related to Hand Preference for Men Undergoing Treatment of Male Pattern Baldness

19 citations , November 2012 in “BJUI”

In this study, researchers observed that the sexual effects of dihydrotestosterone deprivation using finasteride may vary by handedness, with right-handed men often experiencing lower sexual function and left-handed men showing no effect or improvement.

research Secondary Infertility Due to Use of Low-Dose Finasteride

15 citations , October 2012 in “International Urology and Nephrology”

This case report describes a 40-year-old man whose secondary infertility, observed after prolonged finasteride use for hair loss, resolved following discontinuation of the drug, resulting in a live birth.

research Finasteride-Induced Secondary Infertility Associated with Sperm DNA Damage

36 citations , February 2011 in “Fertility and Sterility”

This case report suggests that discontinuing low-dose finasteride in a 48-year-old man led to a significant reduction in sperm DNA fragmentation index, indicating a possible link between finasteride and sperm DNA damage.

Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

research Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

223 citations , December 2010 in “The Journal of Sexual Medicine”

This review discusses persistent adverse effects of 5α‐reductase inhibitors, like diminished libido and erectile dysfunction, in some patients and highlights the need for patient discussions before therapy, especially for androgenetic alopecia.

Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

research Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

45 citations , August 2010 in “Hormone Molecular Biology and Clinical Investigation”

This study found that SRD5a-3 is a highly efficient enzyme for converting hormones into androgens, with dutasteride being a much more potent inhibitor of SRD5a-3 than SRD5a-2.

research Finasteride Treatment and Neuroactive Steroid Formation

9 citations , January 2009 in “PubMed”

This study found that finasteride treatment in men with benign prostate hyperplasia significantly altered steroid hormone profiles and may contribute to depressive symptoms by affecting neuroactive steroid levels.