Safety Profile of Finasteride: Distribution of Adverse Effects According to Structural and Informational Dichotomies of the Mind/Brain

    February 2017 in “ Clinical Drug Investigation ”
    Ion G. Motofei, David L. Rowland, Mirela Manea … Ioanel Sinescu
    Studysummary This paper discusses the adverse effects of finasteride, including sexual dysfunction and depression, and suggests that treatment customization based on individual factors like hand preference and sexual orientation could improve outcomes and reduce these side effects.
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    Research cited in this study 15

    1. Atypical Post-Finasteride Syndrome: A Pharmacological Riddle Indian Journal of Pharmacology · 2016
    2. Finasteride Adverse Effects in Subjects with Androgenic Alopecia: A Possible Therapeutic Approach According to the Lateralization Process of the Brain Journal of Dermatological Treatment · 2016
    3. Are Hand Preference And Sexual Orientation Possible Predicting Factors For Finasteride Adverse Effects In Male Androgenic Alopecia? Experimental Dermatology · 2016
    4. An Observational Retrospective Evaluation of 79 Young Men with Long-Term Adverse Effects After Use of Finasteride Against Androgenetic Alopecia International Journal of Andrology · 2016
    5. Persistent Sexual Dysfunction and Suicidal Ideation in Young Men Treated with Low-Dose Finasteride: A Pharmacovigilance Study Pharmacotherapy · 2015
    6. Safety Concerns Regarding 5α Reductase Inhibitors for the Treatment of Androgenetic Alopecia Current Opinion in Endocrinology, Diabetes and Obesity · 2015
    7. Androgenetic Alopecia: An Evidence-Based Treatment Update American Journal of Clinical Dermatology · 2014
    8. Patients Treated for Male Pattern Hair Loss with Finasteride Show Altered Levels of Neuroactive Steroids in Cerebrospinal Fluid and Plasma After Discontinuation The Journal of Steroid Biochemistry and Molecular Biology · 2014
    9. Decreased Alcohol Consumption Among Former Male Users of Finasteride with Persistent Sexual Side Effects: A Preliminary Report Alcoholism: Clinical and Experimental Research · 2013
    10. A Pilot Study on the Sexual Side Effects of Finasteride as Related to Hand Preference for Men Undergoing Treatment of Male Pattern Baldness BJUI · 2012
    11. Secondary Infertility Due to Use of Low-Dose Finasteride International Urology and Nephrology · 2012
    12. Finasteride-Induced Secondary Infertility Associated with Sperm DNA Damage Fertility and Sterility · 2011
    13. Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients The Journal of Sexual Medicine · 2010
    14. Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride Hormone Molecular Biology and Clinical Investigation · 2010
    15. Finasteride Treatment and Neuroactive Steroid Formation PubMed · 2009

    Related research 7

    1. Safety Profile of Finasteride: Distribution of Adverse Effects According to Structural and Informational Dichotomies of the Mind/Brain Clinical Drug Investigation · 2017
    2. Post-Finasteride Adverse Effects in Male Androgenic Alopecia: A Case Report of Vitiligo Skin Pharmacology and Physiology · 2017
    3. Differences in Reproductive Toxicology Between Alopecia Drugs: An Analysis on Adverse Events Among Female and Male Cases Oncotarget · 2016
    4. Finasteride Adverse Effects and Post-Finasteride Syndrome: Implications for Dentists Journal of Mind and Medical Sciences · 2016
    5. Are Hand Preference And Sexual Orientation Possible Predicting Factors For Finasteride Adverse Effects In Male Androgenic Alopecia? Experimental Dermatology · 2016
    6. Finasteride in the Treatment of Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2004
    7. Effect of Finasteride, a 5 Alpha-Reductase Inhibitor, on Serum Gonadotropins in Normal Men The Journal of Clinical Endocrinology and Metabolism · 1992