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Progesterone-Induced Stimulation of Mammary Tumorigenesis Is Due to the Progesterone Metabolite, 5α-Dihydroprogesterone (5αP), and Can Be Suppressed by the 5α-Reductase Inhibitor, Finasteride

research Progesterone-Induced Stimulation of Mammary Tumorigenesis Is Due to the Progesterone Metabolite, 5α-Dihydroprogesterone (5αP), and Can Be Suppressed by the 5α-Reductase Inhibitor, Finasteride

21 citations , January 2015 in “The Journal of Steroid Biochemistry and Molecular Biology”

Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.

research The Neurosteroid Metabolite of Progesterone, 3α-OH-Dihydroprogesterone (3α-OH-DHP), Is Required for Attenuated Baroreflex Mediated Sympathoexcitation in Pregnancy

1 citations , April 2013 in “The FASEB Journal”

3α‐OH‐DHP is essential for reducing nerve activity related to blood pressure control during pregnancy.

research Exploring the Impact of the Microbiome on Neuroactive Steroid Levels in Germ-Free Animals

11 citations , November 2021 in “International journal of molecular sciences”

Gut microbes significantly affect brain steroid levels.

research Safety Profile of Finasteride: Distribution of Adverse Effects According to Structural and Informational Dichotomies of the Mind/Brain

8 citations , February 2017 in “Clinical Drug Investigation”

Finasteride can cause sexual dysfunction and depression, which may persist and require hormonal treatment.

Sexually Dimorphic Effect of Progesterone and Its Reduced Metabolites on the Gene Expression of Myelin Proteins in Rat Schwann Cells

research Sexually Dimorphic Effect of Progesterone and Its Reduced Metabolites on the Gene Expression of Myelin Proteins in Rat Schwann Cells

May 2006 in “Frontiers in Neuroendocrinology”

Progesterone and its metabolites affect myelin protein expression differently in male and female rat Schwann cells.

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Community Join

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community How finasteride lowers brain's happiness steroid allopregnanolone and causes depression: systemic dihydroprogesterone crosses blood brain barrier, you don't even need finasteride and brain 5ar for that

in Finasteride/Dutasteride 290 upvotes 5 months ago

Finasteride may lower allopregnanolone levels, potentially affecting mood, but many users report improved mental health due to reduced hair loss. Experiences with finasteride and dutasteride vary, with some experiencing side effects and others finding them beneficial for hair retention and overall happiness.

community risks with finasteride and dutasteride

in Research/Science 140 upvotes 4 months ago

Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

community Trying to understand finasteride side effects and post finasteride syndrome

in Finasteride/Dutasteride 72 upvotes 5 years ago

The conversation discusses the side effects of finasteride, including low libido and erectile dysfunction, and the possibility of these effects being permanent, known as post-finasteride syndrome (PFS). Some users report personal experiences with PFS and debate whether the condition is real, with varying opinions on the reversibility of side effects and the role of individual biology.

community How come dutasteride doesn't lower allopregnanolone, but finasteride does?

in Finasteride/Dutasteride 12 upvotes 10 months ago

Finasteride significantly lowers allopregnanolone levels, while dutasteride's effect is less clear and may vary. Some users speculate that dutasteride might be healthier for the brain due to its different inhibition pathways.

community My hair after 3 steroid cycles

in Progress Pictures 27 upvotes 1 year ago

A user shared their hair progress after three steroid cycles, using 5% minoxidil and 100mg RU58841 daily. They are considering a hair transplant due to paranoia about shedding.

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