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Progesterone byproduct 5αP stimulates mammary tumor growth, but finasteride can suppress it.

Gut microbes significantly affect brain steroid levels.

Finasteride can cause sexual dysfunction and depression, which may persist and require hormonal treatment.

Progesterone and its metabolites affect myelin protein expression differently in male and female rat Schwann cells.

Lower levels of certain brain chemicals are linked to worse PTSD symptoms in men.

This enzyme helps metabolize fatty acids and isoleucine, and could be key in treating neurological diseases and certain cancers.

Finasteride may affect fetal brain development and increase arousal, but more research is needed for safety confirmation.

5α reductase inhibitors treat hair loss but may cause sexual side effects and risks.

Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.

Finasteride may cause long-lasting sexual side effects.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

Finasteride use changes brain chemicals, causing lasting sexual issues and anxiety/depression.

Finasteride affects brain and blood steroids, causing lasting sexual and emotional side effects.

Finasteride almost fully depletes allopregnanolone in rat brains and enhances 20α-DHP, but doesn't change 3α-DHP levels.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

Finasteride affects alcohol intake in male mice, possibly due to neurosteroids.

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

Neuroactive steroids could become safe, effective treatments with more understanding of their complex brain actions and metabolism.

Post-finasteride syndrome causes lasting sexual, neurological, and physical side effects in some people after taking finasteride.

Stress worsens Tourette symptoms by increasing allopregnanolone levels.

Finasteride may increase depression by reducing brain cell growth.

Finasteride helps protect brain in old male rats.

Allopregnanolone is needed for certain brain processing issues caused by D1 dopamine receptor activation.

5α-reductase inhibitors like finasteride may not be effective or safe for transgender individuals, and more research is needed.

Korean and Caucasian men with male pattern baldness have different hair steroid levels.

Finasteride affects SRD5A2 gene pattern, possibly causing lasting side effects.

Inhibiting 5α-reductase increases progesterone levels in late pregnant mares.

Finasteride doesn't affect ovulation in normal women.

A new method was created to test the effectiveness of Dihydrotestosterone (DHT) inhibitors, like finasteride and dutasteride, in human and fish cells. The results showed fish cells are more sensitive to these treatments, and dutasteride works better than finasteride in all tested cells.