Post-Finasteride Adverse Effects in Male Androgenic Alopecia: A Case Report of Vitiligo

    January 2017 in “ Skin Pharmacology and Physiology ”
    Ion G. Motofei, David L. Rowland, Simona Roxana Georgescu, Mircea Tampa, Stana Paunica, Vlad Denis Constantin, Cristian Balalau, Mirela Manea, Bogdan C. Baleanu, Ioanel Sinescu
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    TLDR Finasteride may cause vitiligo, sexual issues, and depression; better treatments and predicting side effects needed.
    A case report discusses a 52-year-old man who developed vitiligo, mild sexual dysfunction, and moderate depressive symptoms after taking finasteride for male androgenic alopecia. The report suggests that further studies should explore therapeutic approaches that not only decrease circulating dihydrotestosterone levels but also block dihydrotestosterone receptors, particularly those with selective tropism towards the skin. Additionally, the possibility of predicting adverse effects of finasteride based on hand preference and sexual orientation should be considered.
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