Pentacyclic Triterpenoid Maslinic Acid Promotes Hair Growth Comparable to Minoxidil: A New Insight on the Potential Involvement of Cilia Activity

    Aprill Kee Oliva Mizushima, Meryem Bouhoute, Meriem Bejaoui, Farhana Ferdousi, Mitsutoshi Nakajima, Hiroko Isoda
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    TLDR Maslinic acid from olive extracts promotes hair growth like minoxidil.
    Maslinic acid, a component of olive extracts, promotes hair growth in mice similarly to minoxidil by accelerating anagen induction. The study found that maslinic acid increases protein levels of CTNNB1 and VEGF and upregulates trichogenic genes such as CTNNB1, ALPL, and FGF1. It activates key pathways like Wnt, Notch, MAPK, and angiogenesis, and suggests a novel link between hair growth and cilia activity, as evidenced by the upregulation of the ciliogenesis-promoting gene Iqcb1. Inhibiting cilia activity led to the downregulation of CTNNB1, indicating that maslinic acid may stimulate hair growth through the Wnt/β-catenin pathway and ciliary gene activity.
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