Pentacyclic Triterpenoid Maslinic Acid Promotes Hair Growth Comparable to Minoxidil: A New Insight on the Potential Involvement of Cilia Activity

    July 2025 in “ ACS Pharmacology & Translational Science ”
    Aprill Kee Oliva Mizushima, Meryem Bouhoute, Meriem Bejaoui … Hiroko Isoda
    Studysummary In this study, maslinic acid applied topically was observed to stimulate hair growth in mice comparably to minoxidil, primarily activating pathways like Wnt/β-catenin, and suggesting a link between hair growth and cilia activity.
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    Research cited in this study 26

    1. Natural Bioactive Compounds as Potential Sources for Alleviation and Treatment of Androgenetic Alopecia: A Research Advance eFood · 2024
    2. Tenascin-C Expressing Touch Dome Keratinocytes Exhibit Characteristics of All Epidermal Lineages Science Advances · 2024
    3. Studying Hair Growth Cycle and Its Effects on Mouse Skin Journal of Investigative Dermatology · 2023
    4. Progenitor-Derived Endothelin Controls Dermal Sheath Contraction for Hair Follicle Regression Nature cell biology · 2023
    5. Role and Mechanisms of Phytochemicals in Hair Growth and Health Pharmaceuticals · 2023
    6. An Overview of the Genetic Aspects of Hair Loss and Its Connection with Nutrition PubMed · 2022
    7. Morphogenesis, Growth Cycle, and Molecular Regulation of Hair Follicles Frontiers in Cell and Developmental Biology · 2022
    8. Epidermal Stem Cells in Hair Follicle Cycling and Skin Regeneration: A View From the Perspective of Inflammation Frontiers in Cell and Developmental Biology · 2020
    9. Systematic Review of Platelet-Rich Plasma Use in Androgenetic Alopecia Compared with Minoxidil, Finasteride, and Adult Stem Cell-Based Therapy International Journal of Molecular Sciences · 2020
    10. Monoterpenoid Loliolide Regulates Hair Follicle Inductivity of Human Dermal Papilla Cells by Activating the Akt/β-Catenin Signaling Pathway Journal of Microbiology and Biotechnology · 2019
    11. Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices Cell · 2017
    12. An Integrated Transcriptome Atlas of Embryonic Hair Follicle Progenitors, Their Niche, and the Developing Skin Developmental cell · 2015
    13. Regulation Mechanisms of Hair Growth Current problems in dermatology · 2015
    14. Fibroblast Growth Factors Stimulate Hair Growth Through Beta-Catenin and Shh Expression in C57BL/6 Mice BioMed Research International · 2015
    15. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    16. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    17. Valproic Acid Induces Hair Regeneration in Murine Model and Activates Alkaline Phosphatase Activity in Human Dermal Papilla Cells PLOS ONE · 2012
    18. Reprogramming Adult Dermis to a Neonatal State Through Epidermal Activation of Beta-Catenin Development · 2011
    19. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007
    20. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    21. Hair Growth Effect of Minoxidil Folia Pharmacologica Japonica · 2002
    22. The Catalog of Human Hair Keratins Journal of Biological Chemistry · 2001
    23. Towards a Molecular Understanding of Hair Loss and Its Treatment Trends in Molecular Medicine · 2001
    24. Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis Journal of Clinical Investigation · 2001
    25. Inhibition of BMP Signaling Affects Growth and Differentiation in the Anagen Hair Follicle The EMBO Journal · 2000
    26. WNT Signaling in the Control of Hair Growth and Structure Developmental biology · 1999

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