LncRNA018392 Promotes Proliferation of Liaoning Cashmere Goat Skin Fibroblasts Through Up-Regulation of CSF1R by Binding to SPI1

April 2023 in “ Research Square (Research Square) ”

Mei Jin, Suhe Lyu, Xinyang Liu, Lixin Cui, Weiyu Fan

lncRNA018392 skin fibroblasts CSF1R SPI1 cell cycle cell proliferation apoptosis melatonin long non-coding RNA fibroblasts colony stimulating factor 1 receptor transcription factor

Studysummary This study found that melatonin-mediated lncRNA018392 accelerated cell proliferation and inhibited apoptosis in cashmere goat skin fibroblasts by upregulating the expression of the nearby gene CSF1R.

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The study reveals that a novel long non-coding RNA (lncRNA018392) plays a significant role in promoting the proliferation of skin fibroblasts in the Liaoning cashmere goat, a breed known for its high fleece production. This lncRNA018392, which is overexpressed, is found to accelerate the cell cycle, facilitate cell proliferation, and inhibit apoptosis by forming a complex with the transcription factor SPI1, thereby up-regulating the expression of the nearby gene CSF1R. The knockdown of lncRNA018392 reversed the effect of melatonin on cell proliferation, and the proliferation of cashmere skin fibroblasts was inhibited when the cells were interfered with the gene CSF1R. These findings provide a theoretical basis for understanding the molecular mechanism of cashmere growth and the molecular breeding of cashmere goats.

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