TLDR LncRNA MTC boosts growth of goat skin cells, improving cashmere quality.
The study investigates the role of LncRNA MTC in enhancing the proliferation of Liaoning cashmere goat skin fibroblasts, which is crucial for improving cashmere quality. Overexpression of LncRNA MTC significantly increased cell proliferation, while its interference suppressed it. The research revealed that melatonin treatment enhances the binding of LncRNA MTC to GSTM1, and this interaction was confirmed through RNA immunoprecipitation. Interfering with GSTM1 reversed the proliferative effects of melatonin. Additionally, GSTM1 was found to associate with ASK1, suggesting that the LncRNA MTC-GSTM1 interaction inhibits apoptosis in these fibroblasts, thereby promoting cashmere growth.
46 citations,
March 2019 in “Journal of Pineal Research” Melatonin improves cashmere goat hair growth and quality by increasing antioxidants and reducing cell death.
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September 2018 in “Naturwissenschaften” Melatonin treatment increases a specific RNA in goat cells that boosts cashmere growth.
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May 2018 in “Frontiers in physiology” Certain RNA molecules are important for the development of wool follicles in sheep.
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September 2022 in “Animal biotechnology” lncRNA MTC affects protein levels in goat skin cells, impacting hair growth.
January 2022 in “Figshare” lncRNA MTC helps goat skin cells grow and may aid hair growth by controlling proteins linked to cell growth.
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September 2018 in “Naturwissenschaften” Melatonin treatment increases a specific RNA in goat cells that boosts cashmere growth.
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August 2024 in “Current Issues in Molecular Biology” Key genes and RNAs related to hair growth in sheep were identified, aiding future breeding improvements.
