Does Maternal Exposure to Artificial Food Coloring Additives Increase Oxidative Stress in the Skin of Rats?

    November 2016 in “ Human & Experimental Toxicology ”
    Kayhan Başak, PY Başak, DK Doğuç, Firdevs Aylak, Serpil Oğuztüzün, Büşra Moran Bozer, Fatih Gültekin
    TLDR Maternal exposure to artificial food coloring may increase skin disease risk in rat offspring.
    The study found that maternal exposure to artificial food coloring additives (AFCAs) in rats significantly altered the expression of enzymes and factors related to oxidative stress in the skin, such as CYP1A1, GSTs, and VEGF, with most showing decreased expression except for GSTM, which increased in sebaceous glands and hair follicles. These changes suggested a potential contribution to neoplastic and nonneoplastic skin diseases. The research involved 30 adult female Wistar albino rats and highlighted the need for further investigation into the effects of individual color additives on skin health.
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