Does Maternal Exposure to Artificial Food Coloring Additives Increase Oxidative Stress in the Skin of Rats?

    November 2016 in “ Human & Experimental Toxicology ”
    Kayhan Başak, PY Başak, DK Doğuç, Firdevs Aylak, Serpil Oğuztüzün, Büşra Moran Bozer, Fatih Gültekin
    TLDR Maternal exposure to artificial food coloring may increase skin disease risk in rat offspring.
    The study investigated the effects of maternal exposure to artificial food coloring additives (AFCAs) on the expression of certain enzymes and growth factors in rat skin. It was found that exposure to AFCAs led to a significant decrease in the expression of CYP1A1, GSTA, GSTT, and VEGF, while GSTM expression increased in sebaceous glands and hair follicles. These changes in expression could potentially contribute to the development of neoplastic and nonneoplastic skin diseases. The study used a rat model where female rats were given "no observable adverse effect levels" of AFCAs before and during gestation, and the skin of their offspring was analyzed.
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