Exploring Mechanisms of the Ligusticum Chuanxiong Hort. and Angelica Sinensis (Oliv.) Diels Pair in Seborrheic Alopecia: An Integrated Data Mining, Network Pharmacology, and Experimental Study

    September 2026 in “ Journal of Traditional Chinese Medical Sciences ”
    Wenjing Zha, 段芳玫, Yaokun Xiong … Jing Luo
    Studysummary In this study, topical application of a combined essential oil from Ligusticum chuanxiong and Angelica sinensis significantly improved hair regrowth in testosterone-induced alopecia in mice, potentially by modulating steroid hormone-related proteins.
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    Research cited in this study 21

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    10. A Network Pharmacology-Based Approach to Explore Mechanism of Action of Medicinal Herbs for Alopecia Treatment Scientific Reports · 2022
    11. Weekly Treatment with SAMiRNA Targeting the Androgen Receptor Ameliorates Androgenetic Alopecia Scientific Reports · 2022
    12. Dihydrotestosterone-Induced Hair Regrowth Inhibition by Activating Androgen Receptor in C57BL6 Mice Simulates Androgenetic Alopecia Biomedicine & Pharmacotherapy · 2021
    13. Targeting Wnt/β-Catenin Pathway for Developing Therapies for Hair Loss International Journal of Molecular Sciences · 2020
    14. A Randomized Controlled Clinical Study of Acupuncture Therapy for Seborrheic Alopecia in Young and Middle-Aged Patients Medicine · 2020
    15. Meta-Analysis on the Efficacy and Safety of Traditional Chinese Medicine as Adjuvant Therapy for Refractory Androgenetic Alopecia Evidence-based Complementary and Alternative Medicine · 2019
    16. Medicinal Plants for the Treatment of Hair Loss and the Suggested Mechanisms Current Pharmaceutical Design · 2018
    17. Exploring the Combination and Modular Characteristics of Herbs for Alopecia Treatment in Traditional Chinese Medicine: An Association Rule Mining and Network Analysis Study BMC Complementary and Alternative Medicine · 2018
    18. Efficacy of Non-Surgical Treatments for Androgenetic Alopecia: A Systematic Review and Network Meta-Analysis Journal of The European Academy of Dermatology and Venereology · 2018
    19. Androgenetic Alopecia: A Review Endocrine · 2017
    20. 11β-Hydroxysteroid Dehydrogenase Type 1 Inhibition Attenuates the Adverse Effects of Glucocorticoids on Dermal Papilla Cells Yonsei Medical Journal · 2017
    21. Angelica Sinensis Induces Hair Regrowth via the Inhibition of Apoptosis Signaling ˜The œAmerican journal of Chinese medicine · 2014