Study on the Regulatory Effect of Ligusticum Chuanxiong on Inflammation of Human Dermal Papilla Cells in Alopecia Areata Based on Network Pharmacology and In Vitro Experiment
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research Female Pattern Hair Loss and Negative Psychological Impact: Possible Role of Brain-Derived Neurotrophic Factor
This study found that women with Female Pattern Hair Loss had lower serum BDNF levels, which correlated with higher stress and depression, suggesting BDNF as a potential marker for psychological impacts in these patients.
research Biomarkers in Alopecia Areata: A Systematic Review and Meta-Analysis
This systematic review and meta-analysis reports that patients with alopecia areata have significantly higher serum levels of IL6 and CRP, and lower levels of vitamin D, compared to healthy controls.
research Serum Brain-Derived Neurotrophic Factor and Vitamin D: Two Concordant Players Controlling Depression Among Alopecia Areata and Vitiligo Patients: A Case-Control Study
In this study, alopecia areata and vitiligo patients had significantly lower serum BDNF and vitamin D levels, which were inversely associated with depression and quality of life, suggesting a potential combined role in the development of depression.
research Laser and Light Therapy Combined With Topical Minoxidil for Alopecia Areata: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
research Alopecia Areata: A Review of the Role of Oxidative Stress, Possible Biomarkers, and Potential Novel Therapeutic Approaches
This review discusses oxidative stress in alopecia areata pathogenesis and potential treatment strategies, reporting no new clinical results but suggesting biomarkers for oxidative stress and discussing JAK inhibitors as promising options.
research Emerging Drugs for the Treatment of Alopecia Areata
This review reports on new and effective drug developments for treating severe alopecia areata, including oral baricitinib, but emphasizes that no treatment guarantees permanent remission or works for all patients, with high recurrence rates after stopping medication.
research Lifestyle Factors Involved in the Pathogenesis of Alopecia Areata
This review summarizes the influences of lifestyle factors such as smoking, alcohol, and diet on the pathogenesis of alopecia areata but reports no new clinical results.
research Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management
JAK inhibitors show promise for treating alopecia areata, but more research is needed.
research A Comprehensive Literature Review of JAK Inhibitors in the Treatment of Alopecia Areata
This review explores the efficacy and outcomes of using JAK inhibitors for treating alopecia areata, noting advancements in understanding the disease's pathomechanisms and suggesting that JAK inhibitors may offer targeted therapeutic benefits by blocking specific inflammatory pathways involved in this chronic condition.
research Mesenchymal Stem Cells Antagonize IFN-Induced Proinflammatory Changes and Growth Inhibition Effects via Wnt/β-Catenin and JAK/STAT Pathway in Human Outer Root Sheath Cells and Hair Follicles
This study found that human hematopoietic mesenchymal stem cells increased the viability and migration of human outer root sheath cells in an in vitro alopecia areata model, involving Wnt/β-catenin and JAK/STAT pathways.
research Alopecia Areata: A Review on Diagnosis, Immunological Etiopathogenesis, and Treatment Options
This review highlights the challenges in treating alopecia areata, noting that current therapies often lead to relapse and have uncertain long-term effectiveness; it also points to potential future treatments such as JAK-STAT inhibitors and PRP.
research Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata
This review discusses immune privilege in anagen hair follicles and its collapse in alopecia areata, emphasizing the importance of restoring this function for effective management and disease relapse prevention.
research Frontiers in Alopecia Areata Pathobiology Research
This review discusses emerging research areas in alopecia areata pathobiology, highlighting the potential roles of unconventional immune cells and the need for more targeted therapeutic strategies, but reports no new experimental results.
research Alopecia Areata: A Multifactorial Autoimmune Condition
This review discusses genetic and environmental factors contributing to autoimmunity in alopecia areata and reports no new clinical findings, emphasizing the need for further study on its aetiology and pathophysiology.
research Alopecia Areata: Overview and Insights from January 2018
This article reviews the epidemiology, clinical evaluation, and pathogenesis of alopecia areata and highlights recent advancements, but it does not report new clinical findings.
research Double-Stranded RNA Induces Inflammation via the NF-κB Pathway and Inflammasome Activation in the Outer Root Sheath Cells of Hair Follicles
This study investigated the role of NLRP3 inflammasomes in alopecia areata and found that outer root sheath cells may contribute to inflammation by increasing IL-1β and HMGB1 secretion when stimulated with double-stranded RNA.
research Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth
This study observed that applying JAK-STAT pathway inhibitors to mouse and human skin led to rapid hair growth by inducing the anagen phase of hair follicles.
research Dihydrotestosterone-Inducible IL-6 Inhibits Elongation of Human Hair Shafts by Suppressing Matrix Cell Proliferation and Promotes Regression of Hair Follicles in Mice
IL-6 contributes to hair loss by shortening the growth phase and causing hair follicles to regress.
research Control of Human Hair Growth by Neurotrophins: Brain-Derived Neurotrophic Factor Inhibits Hair Shaft Elongation, Induces Catagen, and Stimulates Follicular Transforming Growth Factor Beta 2 Expression
This study found that brain-derived neurotrophic factor (BDNF) inhibited hair shaft elongation and induced premature catagen development in cultured human hair follicles, partially through transforming growth factor β2.
Related Research
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research Serum Zinc Concentration in Patients With Alopecia Areata
This study found that patients with severe alopecia areata had significantly lower serum zinc levels compared to healthy controls, and a negative correlation between zinc levels and disease severity was observed, suggesting that zinc assessment and supplementation trials may be warranted in this population.