Serum Brain-Derived Neurotrophic Factor and Vitamin D: Two Concordant Players Controlling Depression Among Alopecia Areata and Vitiligo Patients: A Case-Control Study

This case-control study examined 30 patients with alopecia areata (AA), 30 with vitiligo, and 30 healthy controls, focusing on serum levels of brain-derived neurotrophic factor (BDNF) and vitamin D, and their correlation with depression and quality of life. The study found that both BDNF and vitamin D levels were significantly lower in AA and vitiligo patients, correlating with higher depression severity and lower quality of life. Vitamin D deficiency was prevalent in 86.6% of AA and 90% of vitiligo patients. Lower levels of these markers were associated with more severe disease and higher depression scores, suggesting their role in the pathophysiology of these conditions and potential therapeutic benefits of vitamin D supplementation.