The Human Type I Keratin Gene Family: Characterization of New Hair Follicle Specific Members and Evaluation of the Chromosome 17q21.2 Gene Domain

    December 2004 in “ Differentiation ”
    Michael A. Rogers, Hermelita Winter, Lutz Langbein … Jürgen Schweizer
    Studysummary This study identifies six novel keratin genes from the chromosome 17q21.2 region, suggesting their association with hair follicles, while all 27 keratin genes in the domain have been characterized transcriptionally.
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    Research cited in this study 33

    1. Keratins of the Human Hair Follicle International review of cytology · 2005
    2. Expression of Hair Keratins in the Adult Nail Unit: An Immunohistochemical Analysis of Onychogenesis in the Proximal Nail Fold, Matrix, and Nail Bed British Journal of Dermatology · 2004
    3. Identification of Two Novel Clusters of Ultrahigh-Sulfur Keratin-Associated Protein Genes on Human Chromosome 11 Biochemical and Biophysical Research Communications · 2004
    4. A Novel Mouse Type I Intermediate Filament Gene, Keratin 17n, Exhibits Preferred Expression in Nail Tissue Journal of Investigative Dermatology · 2004
    5. Functional Analysis of Keratin Components in the Mouse Hair Follicle Inner Root Sheath British Journal of Dermatology · 2004
    6. A Cluster of 21 Keratin-Associated Protein Genes Within Introns of Another Gene on Human Chromosome 21q22.3 Genomics · 2004
    7. Hair Keratin Associated Proteins: Characterization of a Second High Sulfur KAP Gene Domain on Human Chromosome 21 in Fond Memory of Dr. Peter Steinert ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 2004
    8. Type II Epithelial Keratin 6hf (K6hf) Is Expressed in the Companion Layer, Matrix, and Medulla in Anagen-Stage Hair Follicles Journal of Investigative Dermatology · 2003
    9. K6irs1, K6irs2, K6irs3, And K6irs4 Represent The Inner-Root-Sheath-Specific Type II Epithelial Keratins Of The Human Hair Follicle Journal of Investigative Dermatology · 2003
    10. Characterization of a First Domain of Human High Glycine-Tyrosine and High Sulfur Keratin-Associated Protein Genes on Chromosome 21q22.1 Journal of biological chemistry/˜The œJournal of biological chemistry · 2002
    11. Polymorphisms in the Human High Sulfur Hair Keratin-Associated Protein 1, KAP1, Gene Family Journal of biological chemistry/˜The œJournal of biological chemistry · 2002
    12. A Novel Epithelial Keratin, hK6irs1, Is Expressed Differentially in All Layers of the Inner Root Sheath, Including Specialized Huxley Cells of the Human Hair Follicle Journal of Investigative Dermatology · 2002
    13. The Catalog of Human Hair Keratins Journal of Biological Chemistry · 2001
    14. Genes for Intermediate Filament Proteins and the Draft Sequence of the Human Genome Journal of Cell Science · 2001
    15. Characterization of a Cluster of Human High/Ultrahigh Sulfur Keratin-Associated Protein Genes Embedded in the Type I Keratin Gene Domain on Chromosome 17q12-21 Journal of biological chemistry/˜The œJournal of biological chemistry · 2001
    16. A Unique Type I Keratin Intermediate Filament Gene Family Is Abundantly Expressed in the Inner Root Sheaths of Sheep and Human Hair Follicles Journal of Investigative Dermatology · 2001
    17. Characterization of a 300 Kbp Region of Human DNA Containing the Type II Hair Keratin Gene Domain Journal of Investigative Dermatology · 2000
    18. Keratin Expression in the Normal Nail Unit: Markers of Regional Differentiation British Journal of Dermatology · 2000
    19. Genomic Organization and Amplification of the Human Keratin 15 and Keratin 19 Genes Biochemical and Biophysical Research Communications · 2000
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    21. A Novel Human Type II Cytokeratin, K6hf, Specifically Expressed in the Companion Layer of the Hair Follicle ˜The œjournal of investigative dermatology/Journal of investigative dermatology · 1998
    22. Characterization of a 190-Kilobase Pair Domain of Human Type I Hair Keratin Genes Journal of biological chemistry/˜The œJournal of biological chemistry · 1998
    23. Genomic Characterization of the Human Type I Cuticular Hair Keratin hHa2 and Identification of an Adjacent Novel Type I Hair Keratin Gene hHa5 Journal of Investigative Dermatology · 1996
    24. Keratin 19 as a Biochemical Marker of Skin Stem Cells In Vivo and In Vitro: Localization and Variation with Age and Culture Stage Journal of Cell Science · 1996
    25. Sequence Data and Chromosomal Localization of Human Type I and Type II Hair Keratin Genes Experimental Cell Research · 1995
    26. A cDNA Encoding the Human Type I Hair Keratin hHa1 Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression · 1995
    27. A Novel Human Type I Hair Keratin Gene: Evidence For Two Keratin HHa3 Isoforms Molecular Biology Reports · 1995
    28. Keratin 19: Predicted Amino Acid Sequence and Broad Tissue Distribution Suggest It Evolved from Keratinocyte Keratins Journal of Investigative Dermatology · 1989
    29. Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues II: Concomitant and Mutually Exclusive Synthesis of Trichocytic and Epithelial Cytokeratins in Diverse Human and Bovine Tissues (Hair Follicle, Nail Bed and Matrix, Lingual Papilla, Thymic Reticulum) Differentiation · 1988
    30. Patterns of Expression of Trichocytic and Epithelial Cytokeratins in Mammalian Tissues: Human and Bovine Hair Follicles Differentiation · 1988
    31. A Group of Type I Keratin Genes on Human Chromosome 17: Characterization and Expression Molecular and Cellular Biology · 1988
    32. Keratins of the Human Hair Follicle: Hyperproliferative Keratins Consistently Expressed in Outer Root Sheath Cells In Vivo and In Vitro Differentiation · 1987
    33. Differential Expression of Keratin 19 in Normal Human Epithelial Tissues Revealed by Monospecific Monoclonal Antibodies The Histochemical Journal · 1986

    Related research 1

    1. Keratin 19: Predicted Amino Acid Sequence and Broad Tissue Distribution Suggest It Evolved from Keratinocyte Keratins Journal of Investigative Dermatology · 1989