Genomic Organization and Amplification of the Human Keratin 15 and Keratin 19 Genes

    January 2000 in “ Biochemical and Biophysical Research Communications ”
    Neil V. Whittock, Robin A.J. Eady, John A. McGrath
    TLDR The study mapped keratin 15 and 19 genes, aiding future genetic disorder research.
    The study characterized the genomic organization of the human keratin 15 and keratin 19 genes, which were considered potential candidates for uncharacterized genetic disorders of keratinization affecting the skin, nails, hair, and conjunctiva. The keratin 15 gene was found to have 8 exons spanning approximately 5.1 kb, while the keratin 19 gene had 6 exons covering about 4.7 kb, both located on chromosome 17q21. A PCR-based mutation detection strategy was developed to facilitate future analyses, involving primers on flanking introns and direct sequencing of PCR products.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 166 results

      community Losing ground after 14 months of fin use and 11 months of min

      in Finasteride/Dutasteride  51 upvotes 3 years ago
      A 24-year-old person who is worried about their hair loss after 14 months of taking finasteride and 11 months of minoxidil. Replies to the post suggested sticking with their current regimen, that shedding from one part may not be telogen effluvium, and that shedding is normal with these drugs and they should evaluate in two to three months.

      community My personal experience/observations fighting AGA seriously for 5 years

      in Treatment  49 upvotes 1 year ago
      Minoxidil with alcohol and propylene glycol was more effective than non-alcohol versions, and RU58841 worked best in a non-water-based solution. Oral finasteride showed better results than topical, despite side effects; microneedling and tretinoin worsened hair loss, and PRP was only helpful when younger.

      community Hairloss has destroyed my Life completely

      in Chat  339 upvotes 6 months ago
      A young person is distressed about rapid hair loss despite using finasteride and recently starting oral minoxidil. Many suggest continuing treatment, considering dutasteride, and seeking therapy for mental health support.

      community Balding absolutely ruined my life at 17.

      in Finasteride/Dutasteride  210 upvotes 1 year ago
      A user is struggling with hair loss at 17 and has been using finasteride for 5 months and minoxidil for 11 months without seeing regrowth. Other users encourage continuing treatment, sharing their own experiences with finasteride, minoxidil, and dermarolling, and emphasizing patience and acceptance.

    Related Research

    1 / 1 results