Association of JAK1 and JAK2 Gene Polymorphism With Alopecia Areata Risk: A Case-Control Genetic Study

    Zeinab Mahmoud kadry, Haisam Abdelrhman, Essam El Din Abd-El Aziz Nada … Zeinab Abu El Baha Gouda
    Studysummary This study found that the JAK1 rs310241 AG genotype is associated with a 4.6-fold increased risk of alopecia areata, whereas JAK2 polymorphisms showed no significant link, suggesting a potential genetic susceptibility factor warranting further research.
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    Research cited in this study 22

    1. Janus Kinase Inhibitors for Alopecia Areata: A Review of Clinical Data Frontiers in Immunology · 2025
    2. Investigating the Genetic Association of Selected Candidate Loci with Alopecia Areata Susceptibility in Jordanian Patients Medicina · 2025
    3. Genetic Polymorphisms of Immunity Regulatory Genes and Alopecia Areata Susceptibility in Jordanian Patients Medicina · 2024
    4. Genome-Wide Association Study of Alopecia Areata in Taiwan: The Conflict Between Individuals and Hair Follicles Clinical, cosmetic and investigational dermatology · 2023
    5. Recent Advances in the Genetics of Alopecia Areata Medizinische Genetik · 2023
    6. Alopecia Areata Treatment Patterns, Healthcare Resource Utilization, and Comorbidities in the US Population Using Insurance Claims Advances in Therapy · 2021
    7. Candidate Gene Analysis of Alopecia Areata in Jordanian Population of Arab Descent: A Case-Control Study The application of clinical genetics · 2019
    8. The Use of Janus Kinase Inhibitors in Alopecia Areata: A Review of the Literature Journal of cutaneous medicine and surgery · 2019
    9. Alopecia Areata: A Multifactorial Autoimmune Condition Journal of autoimmunity · 2018
    10. Spontaneous Quick Resolution of Uncombable Hair Syndrome-Like Disease Skin appendage disorders · 2018
    11. Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2017
    12. Functional Interpretation of Genome-Wide Association Study Evidence in Alopecia Areata Journal of Investigative Dermatology · 2015
    13. Pharmacologic Inhibition of JAK-STAT Signaling Promotes Hair Growth Science Advances · 2015
    14. Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib EBioMedicine · 2015
    15. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    16. Exomic Sequencing of Immune-Related Genes Reveals Novel Candidate Variants Associated with Alopecia Universalis PLoS ONE · 2013
    17. Alopecia Areata: An Autoimmune Disease Causing Hair Loss The New England Journal of Medicine · 2012
    18. Investigative Guidelines for Alopecia Areata Dermatologic therapy · 2011
    19. The Genetics of Alopecia Areata: What's New and How Will It Help Our Patients? Dermatologic therapy · 2011
    20. Etiopathogenesis of Alopecia Areata: Why Do Our Patients Get It? Dermatologic therapy · 2011
    21. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    22. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007