Genetic Polymorphisms of Immunity Regulatory Genes and Alopecia Areata Susceptibility in Jordanian Patients

    October 2024 in “ Medicina ”
    Mansour A. Alghamdi, Laith N. AL‐Eitan, Hanan A. Aljamal, Hana Abu Kharmah
    TLDR CLEC4D gene variants may increase the risk of alopecia areata in Jordanians.
    This study investigated the genetic basis of alopecia areata (AA) in the Jordanian population by analyzing DNA from 152 patients and 150 healthy subjects. The research focused on identifying genetic polymorphisms associated with AA susceptibility. While no significant associations were found in ten single-nucleotide polymorphisms (SNPs), the study identified significant associations between the <i>CLEC4D</i> rs4304840 variants and AA development, particularly in the codominant and recessive forms. These findings suggest that <i>CLEC4D</i> gene variants may play a role in the pathogenesis of AA among Jordanians, highlighting the need for further genetic and functional studies to better understand the disease.
    Discuss this study in the Community →

    Research cited in this study

    8 / 8 results

    Related Community Posts Join

    6 / 1000+ results

      community My experience and a discourse on “DUPA”

      in Chat  46 upvotes 3 years ago
      How diffuse unpatterned alopecia (DUPA) is not an invitation to self-diagnose oneself with aggressive AGA and that seeking a specialized dermatologist may help people experiencing hair loss. Treatment options discussed include topical clobetasol propionate, oral minoxidil, and discontinuing finasteride.

      community Only Minoxidil 2 Months Before After Photos

      in Progress Pictures  132 upvotes 1 year ago
      A user shared their 2-month hair growth progress using only Minoxidil, noting significant improvement and plans to continue despite a genetic predisposition to baldness. They apply Minoxidil twice daily, experienced a heat rash, and chose not to use Finasteride due to side effects.

      community Pattern hair loss could be due to gut bacteria

       51 upvotes 6 years ago
      Feeding bacteria-free mice with Lactobacillus murinus worsened hair loss, but a regular diet with biotin stopped it. The conversation suggests gut bacteria and diet may influence hair loss, with some skepticism and discussion about other factors like DHT and genetics.

    Related Research

    1 / 1 results