Genetic Polymorphisms of Immunity Regulatory Genes and Alopecia Areata Susceptibility in Jordanian Patients

    October 2024 in “ Medicina ”
    Mansour A. Alghamdi, Laith N. AL‐Eitan, Hanan A. Aljamal, Hana Abu Kharmah
    Studysummary In this genetic study, the researchers found that variants in the CLEC4D gene are significantly associated with the development of alopecia areata among individuals in the Jordanian population, pointing to a potential genetic influence on the disease's pathogenesis.
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    Research cited in this study 8

    1. Immunology of Alopecia Areata Central-European Journal of Immunology/Central European Journal of Immunology · 2020
    2. Candidate Gene Analysis of Alopecia Areata in Jordanian Population of Arab Descent: A Case-Control Study The application of clinical genetics · 2019
    3. Genes and Immune Response in Alopecia Areata: Review of the Alopecia Areata Research Summit First Day Proceedings Journal of Investigative Dermatology Symposium Proceedings · 2013
    4. Exomic Sequencing of Immune-Related Genes Reveals Novel Candidate Variants Associated with Alopecia Universalis PLoS ONE · 2013
    5. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    6. An Update on Alopecia Areata Current opinion in pediatrics, with evaluated MEDLINE/Current opinion in pediatrics · 2009
    7. Role of the Autoimmune Regulator (AIRE) Gene in Alopecia Areata: Strong Association of a Potentially Functional AIRE Polymorphism With Alopecia Universalis Tissue Antigens · 2002
    8. Alopecia Areata: Animal Models Clinical and Experimental Dermatology · 2002

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