Genetic Polymorphisms of Immunity Regulatory Genes and Alopecia Areata Susceptibility in Jordanian Patients

October 2024 in “ Medicina ”

Mansour A. Alghamdi, Laith N. AL‐Eitan, Hanan A. Aljamal, Hana Abu Kharmah

alopecia areata genetic polymorphisms CLEC4D single-nucleotide polymorphisms SNPs AA

Studysummary In this genetic study, the researchers found that variants in the CLEC4D gene are significantly associated with the development of alopecia areata among individuals in the Jordanian population, pointing to a potential genetic influence on the disease's pathogenesis.

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The study examined the genetic basis of alopecia areata (AA) in 152 Jordanian patients compared to 150 healthy controls, focusing on immunity regulatory genes. It found a significant association between the CLEC4D rs4304840 SNP and AA, particularly in codominant and recessive forms, suggesting this gene variant may play a role in AA development. However, no significant associations were found with other genes after Bonferroni correction. The findings indicate the complexity of genetic factors in AA susceptibility and emphasize the need for further research to understand the disease's molecular pathogenesis.

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research Alopecia Areata: Animal Models

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