Indole Glycosides from Calanthe Discolor with Proliferative Activity on Human Hair Follicle Dermal Papilla Cells

May 2021 in “ Chemical & Pharmaceutical Bulletin ”

Toshio Morikawa, Yoshiaki Manse, Fenglin Luo, Haruko Fukui, Yamato Inoue, Tsuyoshi Kaieda, Kiyofumi Ninomiya, Osamu Muraoka, Masayuki Yoshikawa

Calanthe discolor indole glycosides human hair follicle dermal papilla cells HFDPC 6′-O-β-D-apiofuranosylindican glucoindican calanthoside vascular endothelial growth factor VEGF fibroblast growth factor-7 FGF-7 hair follicle cells dermal papilla cells growth factors

TLDR Extracts from the Calanthe discolor plant promote hair follicle growth and increase growth factor levels.

The study found that a methanol extract from the underground part of Calanthe discolor Lindl. (Orchidaceae) showed significant proliferative activity on human hair follicle dermal papilla cells (HFDPC) at 100 µg/mL. A new indole glycoside named 6′-O-β-D-apiofuranosylindican (1) was isolated from the extract, along with six known compounds. Among these, compound 1, glucoindican (3), and calanthoside (4) showed significant proliferative activity at 100 µM. These active indole glycosides (1, 3, and 4) also upregulated the expression of vascular endothelial growth factor (VEGF) and fibroblast growth factor-7 (FGF-7) mRNA and protein in HFDPC, suggesting this could be the mechanism of their proliferative activity.

View this study on jstage.jst.go.jp →

Discuss this study in the Community →

Cited in this study

17 / 17 results

research Geranylated Coumarins From Thai Medicinal Plant Mammea Siamensis With Testosterone 5α-Reductase Inhibitory Activity

17 citations , March 2020 in “Frontiers in Chemistry”

Compounds from the plant Mammea siamensis may help treat hair loss.

research Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt Pathway, Growth Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development

136 citations , May 2019 in “Cells”

Stem cell therapy, particularly using certain types of cells, shows promise for treating hair loss by stimulating hair growth and development, but more extensive trials are needed to confirm these findings.

research Review of Hair Follicle Dermal Papilla Cells as In Vitro Screening Model for Hair Growth

76 citations , October 2018 in “International Journal of Cosmetic Science”

Dermal Papilla cells are a promising tool for evaluating hair growth treatments.

research Inhibition of Rat 5α-Reductase Activity and Testosterone-Induced Sebum Synthesis in Hamster Sebocytes by an Extract of Quercus Acutissima Cortex

37 citations , January 2015 in “Evidence-based Complementary and Alternative Medicine”

An extract from Quercus acutissima bark was found to reduce sebum production and block an enzyme linked to acne.

research Potential Targets in the Discovery of New Hair Growth Promoters for Androgenic Alopecia

59 citations , June 2014 in “Expert Opinion on Therapeutic Targets”

The document concludes that targeting 5α-reductase, the androgen receptor, and hair growth genes, along with using compounds with anti-androgenic properties, could lead to more effective hair loss treatments.

research The Human Hair: From Anatomy to Physiology

107 citations , December 2013 in “International Journal of Dermatology”

The document concludes that hair is complex, with a detailed growth cycle, structure, and clinical importance, affecting various scientific and medical fields.

research The 5 Alpha-Reductase Isozyme Family: A Review of Basic Biology and Their Role in Human Diseases

218 citations , January 2012 in “Advances in Urology”

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

research Discovery of a Novel Hybrid from Finasteride and Epristeride as 5α-Reductase Inhibitor

18 citations , January 2011 in “Bioorganic & Medicinal Chemistry Letters”

New hybrid compound found to effectively prevent hair loss.

research Biology and Genetics of Hair

89 citations , September 2010 in “Annual Review of Genomics and Human Genetics”

The document concludes that understanding the genes and pathways involved in hair growth is crucial for developing treatments for hair diseases.

research Human Type 3 5α-Reductase Is Expressed in Peripheral Tissues at Higher Levels Than Types 1 and 2 and Its Activity Is Potently Inhibited by Finasteride and Dutasteride

45 citations , August 2010 in “Hormone Molecular Biology and Clinical Investigation”

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

research Microencapsulated Human Hair Dermal Papilla Cells: A Substitute for Dermal Papilla?

25 citations , April 2008 in “Archives of Dermatological Research”

Encapsulated human hair cells can substitute for natural hair cells to grow hair.

research The Hair Cycle

375 citations , February 2006 in “Journal of Cell Science”

The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.

research Control of Hair Growth and Follicle Size by VEGF-Mediated Angiogenesis

520 citations , February 2001 in “Journal of Clinical Investigation”

VEGF helps hair grow and determines follicle size by increasing blood vessel growth.

research Finasteride and the Hair Cycle

26 citations , May 2000 in “Journal of The American Academy of Dermatology”

Finasteride improves hair growth.

research Androgen-Dependent Beard Dermal Papilla Cells Secrete Autocrine Growth Factors in Response to Testosterone Unlike Scalp Cells

51 citations , November 1998 in “The journal of investigative dermatology/Journal of investigative dermatology”

Beard cells, unlike scalp cells, produce growth factors in response to testosterone, which may explain differences in hair growth.

research Finasteride in the Treatment of Men with Androgenetic Alopecia

581 citations , October 1998 in “Journal of The American Academy of Dermatology”

Finasteride safely and effectively treats male pattern hair loss, but may cause reversible sexual issues and harm male fetuses.

research Hypertrichosis Due to Minoxidil

73 citations , November 1979 in “British Journal of Dermatology”

Minoxidil can cause excessive hair growth.

6 / 6 results

research Possible Cellular Communication with Human Follicle Dermal Papilla Cells via Secretions from Human Hair Follicle Keratinocytes

January 2022 in “Journal of St. Marianna University”

Substances from human hair cells can affect hair loss-related genes, potentially leading to new treatments for baldness.

research A Model System to Analyze the Ability of Human Keratinocytes to Form Hair Follicles

15 citations , May 2014 in “Experimental Dermatology”

Scientists developed a system to study human hair growth using skin cells, which could help understand hair development and improve skin substitutes for medical use.

research Review of Hair Follicle Dermal Cells

321 citations , January 2010 in “Journal of Dermatological Science”

Dermal cells are key in controlling hair growth and could potentially be used in hair loss treatments, but more research is needed to improve hair regeneration methods.