TLDR The cause of Frontal fibrosing alopecia, a type of hair loss, is complex, likely involving immune responses and genetics, but is not fully understood.
Frontal fibrosing alopecia (FFA) is a type of irreversible hair loss, often seen in postmenopausal women, characterized by a receding frontal and temporoparietal hairline. The pathogenesis of FFA is complex and not fully understood, but it is believed to involve immune cell and substance-mediated inflammatory responses, with histological findings showing inflammatory cell infiltration around lesioned hair follicles. The disease is associated with a collapse of immune privilege in hair follicles and is linked to many autoimmune diseases. Factors such as interferon-γ (IFN-γ), epithelial-mesenchymal transition (EMT), peroxisome proliferator-activated receptor γ (PPAR-γ), and the mammalian target of rapamycin (mTOR) signaling pathway play a role in the disease's progression. Genome-wide association analysis indicates that FFA is an immune inflammatory disease with a genetic predisposition, specifically driven by HLA-B*07:02. The roles of sex steroids and external stimuli in FFA are speculative and derived from clinical studies of disease behavior. More extensive studies are needed to confirm the actual pathogenesis of FFA.View this study on frontiersin.org →
Most patients with frontal fibrosing alopecia are postmenopausal women, and treatments like finasteride and dutasteride can improve or stabilize the condition.
Genetics and hormones play a role in male and female hair loss, but more research is needed to fully understand it.
Substance P may worsen acne by increasing inflammation, but corticosteroids might help by reducing this effect.
The best treatment for Frontal Fibrosing Alopecia and Lichen Planopilaris combines oral and topical medications to reduce symptoms and stop hair loss.
Understanding the cause of bitemporal hair loss is key to deciding the right treatment.
The document concludes that understanding and treating hair loss requires recognizing its various types and using appropriate diagnostic tools and treatments.
The most effective treatments for hair loss are minoxidil, finasteride, PRP, and hair transplants, with steroids and immunosuppressants for autoimmune types.
Topical tofacitinib is effective in promoting hair growth for non-scarring alopecia.
Minoxidil promotes hair growth but exact mechanism is unknown.