Foxn1 in Skin Development, Homeostasis and Wound Healing

July 2018 in “ International Journal of Molecular Sciences ”

Joanna Bukowska, Marta Kopcewicz, Katarzyna Walendzik, Barbara Gawrońska‐Kozak

TLDR Foxn1 is crucial for skin development and healing, and altering its expression may aid regenerative medicine.

The document reviewed the role of the transcription factor Foxn1 in skin biology, focusing on its regulatory functions in skin development, homeostasis, and wound healing. It highlighted Foxn1's pivotal role in the transition from fetal to adult skin, which coincided with the loss of scar-free healing ability. The review suggested that genetic manipulations of Foxn1 expression, such as conditional silencing or knock-in models, could offer future prospects for regenerative medicine.

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