TLDR Wnt signaling helps heal injuries and could lead to new treatments.
The document reviewed the role of Wnt signaling in the injury repair process, highlighting its activation by wounding and involvement in various stages of healing, including inflammation control, programmed cell death, and stem cell mobilization at the wound site. It summarized recent data that clarified the functions of the Wnt pathway in tissue repair, providing a basis for developing potential Wnt-based therapies to enhance tissue regeneration.
232 citations
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June 2012 in “Cold Spring Harbor Perspectives in Biology” Wnt signaling helps heal injuries and could lead to new treatments.
89 citations
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January 2009 in “Advances in Clinical Chemistry” Fetal skin heals without scarring due to unique cells and processes not present in adult skin healing.
75 citations
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August 2008 in “PLOS ONE” Wnt3a protein, when packed in liposomal vesicles, can stimulate hair growth and could potentially treat conditions like hair loss.
January 2008 in “The Year book of dermatology” After skin injury, adult mice can grow new hair follicles, and this process can be increased or stopped by manipulating Wnt signals.
220 citations
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August 2007 in “Journal of Bone and Mineral Research” 
829 citations
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May 2007 in “Nature” Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
April 2019 in “Journal of Investigative Dermatology” Wnt-signaling is regulated differently in skin cells and immune responses during wound healing.
