Relative Effects of Minoxidil 5%, Platelet-Rich Plasma, and Microneedling in Pattern Hair Loss: A Systematic Review and Network Meta-Analysis

January 2023 in “ Skin appendage disorders ”

Aditya K. Gupta, Tong Wang, Mary A Bamimore, Shruthi Polla Ravi, Mesbah Talukder

minoxidil platelet-rich plasma microneedling pattern hair loss network meta-analysis Rogaine PRP

TLDR Minoxidil, platelet-rich plasma, and microneedling all help with pattern hair loss, but their effectiveness varies.

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Research cited in this study

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Efficacy and Safety of Combinational Therapy Using Topical Minoxidil and Microneedling for the Treatment of Androgenetic Alopecia: A Systematic Review and Meta-Analysis

research Efficacy and Safety of Combinational Therapy Using Topical Minoxidil and Microneedling for the Treatment of Androgenetic Alopecia: A Systematic Review and Meta-Analysis

September 2023 in “Archives of Dermatological Research”

Using minoxidil with microneedling increases hair count for hair loss without serious side effects.

research Efficacy of Platelet-Rich Plasma in Asians With Androgenetic Alopecia: A Randomized Controlled Trial

September 2022 in “Indian Journal of Dermatology, Venereology and Leprology”

research Platelet-Rich Plasma Monotherapies for Androgenetic Alopecia: A Network Meta-Analysis and Meta-Regression Study

1 citations, August 2022 in “Journal of Drugs in Dermatology”

More frequent PRP sessions with shorter intervals improve hair loss treatment.

research Efficacy and Safety of 5% Minoxidil Alone, Minoxidil Plus Oral Spironolactone, and Minoxidil Plus Microneedling on Female Pattern Hair Loss: A Prospective, Single-Center, Parallel-Group, Evaluator-Blinded, Randomized Trial

2 citations, July 2022 in “Frontiers in Medicine”

Combining minoxidil with microneedling or spironolactone is more effective for female hair loss than using minoxidil alone.

research The Associated Burden of Mental Health Conditions in Alopecia Areata: A Population-Based Study in UK Primary Care

20 citations, February 2022 in “British Journal of Dermatology”

People with alopecia areata have a higher risk of depression and anxiety, and often face unemployment and work absences.

research Comparison Between 5% Minoxidil Plus 2% Flutamide Solution vs. 5% Minoxidil Solution in the Treatment of Androgenetic Alopecia

February 2022 in “Journal of Cosmetic Dermatology”

Using both minoxidil and flutamide together is more effective for treating hair loss than using minoxidil alone.

research Relative Efficacy of Minoxidil and the 5-Alpha Reductase Inhibitors in Androgenetic Alopecia Treatment of Male Patients

13 citations, February 2022 in “JAMA Dermatology”

Dutasteride is the most effective hair loss treatment after 24 weeks, but finasteride leads to the most hair growth after 48 weeks.

The Effect of Placebo in Split-Scalp and Whole-Head Platelet-Rich Plasma Trials for Androgenetic Alopecia Differs: Findings from a Systematic Review with Quantitative Evidence Syntheses

research The Effect of Placebo in Split-Scalp and Whole-Head Platelet-Rich Plasma Trials for Androgenetic Alopecia Differs: Findings from a Systematic Review with Quantitative Evidence Syntheses

January 2022 in “Journal of Cosmetic Dermatology”

Placebo effects vary in hair loss trials, with split-scalp trials showing higher hair density after 6 months compared to whole-head trials.

research A Comparative Study of Efficacy of 5% Minoxidil and 5% Minoxidil Plus Platelet-Rich Plasma in the Same Patient for Treatment of Androgenetic Alopecia

1 citations, January 2022 in “Journal of Cutaneous and Aesthetic Surgery”

research Microneedling and Its Use in Hair Loss Disorders: A Systematic Review

2 citations, December 2021 in “Dermatology and therapy”

Microneedling helps with hair loss, especially with 5% minoxidil, but more high-quality research is needed.

research Microneedling for Hair Loss

9 citations, October 2021 in “Journal of Cosmetic Dermatology”

Microneedling is an effective and minimally invasive treatment for hair loss.

research The Effects of Lower vs Higher Cell Number of Platelet-Rich Plasma on Hair Density and Diameter in Androgenetic Alopecia: A Randomized, Double-Blinded, Placebo, Parallel-Group Half-Scalp IRB-Approved Study

6 citations, May 2021 in “Aesthetic Surgery Journal”

Higher cell number PRP improves hair density and diameter more than lower cell number PRP.

Efficacy of Minoxidil Combined With Photobiomodulation for the Treatment of Male Androgenetic Alopecia: A Double-Blind Half-Head Controlled Trial

research Efficacy of Minoxidil Combined With Photobiomodulation for the Treatment of Male Androgenetic Alopecia: A Double-Blind Half-Head Controlled Trial

May 2021 in “Lasers in Surgery and Medicine”

Minoxidil and photobiomodulation together improve hair growth better than minoxidil alone.

research Efficacy of Cetirizine 1% Versus Minoxidil 5% Topical Solution in the Treatment of Male Alopecia: A Randomized, Single-Blind Controlled Study

7 citations, April 2021 in “Journal of Pharmacy and Pharmaceutical Sciences”

Cetirizine 1% helps hair growth in men with no major side effects, but minoxidil 5% works better.

Platelet-Rich Plasma for Androgenic Alopecia: A Randomized, Placebo-Controlled, Double-Blind Study and Combined Mice Model Experiment

research Platelet-Rich Plasma for Androgenic Alopecia: A Randomized, Placebo-Controlled, Double-Blind Study and Combined Mice Model Experiment

6 citations, March 2021 in “Journal of Cosmetic Dermatology”

PRP injections promote hair growth and increase hair density in androgenic alopecia.

research Scalp Vascularization as a Marker of Topical Minoxidil Treatment Efficacy in Patients with Androgenetic Alopecia

March 2021 in “Postepy Dermatologii I Alergologii”

Minoxidil works equally well for hair growth regardless of scalp blood flow.

Autologous Activated Platelet-Rich Plasma in Hair Growth: A Pilot Study in Male Androgenetic Alopecia with In Vitro Bioactivity Investigation

research Autologous Activated Platelet-Rich Plasma in Hair Growth: A Pilot Study in Male Androgenetic Alopecia with In Vitro Bioactivity Investigation

4 citations, September 2020 in “Journal of Cosmetic Dermatology”

PRP treatment significantly increased hair density and thickness in male hair loss.

Autologous Concentrated Growth Factors Combined With Topical Minoxidil for the Treatment of Male Androgenetic Alopecia: A Randomized Controlled Clinical Trial

research Autologous Concentrated Growth Factors Combined With Topical Minoxidil for the Treatment of Male Androgenetic Alopecia: A Randomized Controlled Clinical Trial

4 citations, August 2020 in “Facial plastic surgery & aesthetic medicine”

Combining growth factors with minoxidil improves hair growth more than minoxidil alone.

Randomized Trial of Electrodynamic Microneedling Combined with 5% Minoxidil Topical Solution for Treating Androgenetic Alopecia in Chinese Males and Molecular Mechanistic Study of the Involvement of the Wnt/β-Catenin Signaling Pathway

research Randomized Trial of Electrodynamic Microneedling Combined with 5% Minoxidil Topical Solution for Treating Androgenetic Alopecia in Chinese Males and Molecular Mechanistic Study of the Involvement of the Wnt/β-Catenin Signaling Pathway

10 citations, May 2020 in “Journal of Dermatological Treatment”

Microneedling with 5% minoxidil improves hair loss in Chinese men by activating Wnt/ß-catenin pathway.

research QR 678 and QR678 Neo vs PRP—A Randomized, Comparative, Prospective Study

14 citations, April 2020 in “Journal of Cosmetic Dermatology”

QR678 treatments were more effective and comfortable for male hair loss than PRP treatments.

research Dermoscopic Assessment of Microneedling Alone Versus Microneedling with Platelet-Rich Plasma in Cases of Male Pattern Alopecia: A Split-Head Comparative Study

5 citations, January 2020 in “International Journal of Trichology”

Microneedling alone is as effective as microneedling with platelet-rich plasma for male pattern baldness.

research Platelet-Rich Plasma Injections in the Treatment of Male Androgenetic Alopecia: A Randomized Placebo-Controlled Crossover Study

9 citations, September 2019 in “Journal of Cosmetic Dermatology”

PRP injections improve hair density in male hair loss.

research Efficacy of Platelet-Rich Plasma for Treating Androgenic Alopecia of Varying Grades

19 citations, June 2019 in “Clinical Drug Investigation”

Platelet-rich plasma injections significantly improve hair density and thickness in both male and female pattern hair loss, especially in early stages.

A Randomized, Investigator-Blinded, Controlled, Split-Scalp Study of the Efficacy and Safety of a 1550-nm Fractional Erbium-Glass Laser, Used in Combination with Topical 5% Minoxidil Versus 5% Minoxidil Alone, for the Treatment of Androgenetic Alopecia

research A Randomized, Investigator-Blinded, Controlled, Split-Scalp Study of the Efficacy and Safety of a 1550-nm Fractional Erbium-Glass Laser, Used in Combination with Topical 5% Minoxidil Versus 5% Minoxidil Alone, for the Treatment of Androgenetic Alopecia

29 citations, April 2019 in “Lasers in Medical Science”

Laser and minoxidil combo promotes better hair growth than minoxidil alone, safely.

research The Effect of the Fractional Carbon Dioxide Laser on Improving Minoxidil Delivery for the Treatment of Androgenetic Alopecia

6 citations, January 2019 in “Journal of lasers in medical sciences”

Using a fractional CO2 laser helps Minoxidil work better for hair regrowth.

research Efficacy of Platelet-Rich Plasma in Androgenetic Alopecia Patients

14 citations, November 2018 in “Journal of Cosmetic Dermatology”

PRP therapy safely improves hair growth in people with hair loss.

Evaluating the Efficacy of Different Platelet-Rich Plasma Regimens for Management of Androgenetic Alopecia: A Single-Center, Blinded, Randomized Clinical Trial

research Evaluating the Efficacy of Different Platelet-Rich Plasma Regimens for Management of Androgenetic Alopecia: A Single-Center, Blinded, Randomized Clinical Trial

46 citations, May 2018 in “Dermatologic Surgery”

PRP injections effectively treat hair loss, with positive results in both monthly and every three months treatments.

Randomized Trial of Electrodynamic Microneedle Combined with 5% Minoxidil Topical Solution for the Treatment of Chinese Male Androgenetic Alopecia

research Randomized Trial of Electrodynamic Microneedle Combined with 5% Minoxidil Topical Solution for the Treatment of Chinese Male Androgenetic Alopecia

28 citations, October 2017 in “Journal of Cosmetic and Laser Therapy”

Combining electrodynamic microneedle with 5% minoxidil improves hair growth and reduces hair loss in Chinese men.

research A Study of the Efficacy of Platelet-Rich Plasma in the Treatment of Androgenetic Alopecia in Males

20 citations, September 2016 in “Indian Journal of Dermatology, Venereology and Leprology”

Platelet-rich plasma treatment significantly increased hair diameter and density, stopped hair fall, and boosted hair growth in men with hair loss, with no reported side effects.

Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

research Randomized Placebo-Controlled, Double-Blind, Half-Head Study to Assess the Efficacy of Platelet-Rich Plasma on the Treatment of Androgenetic Alopecia

136 citations, April 2016 in “Dermatologic Surgery”

PRP treatment helps hair growth and density in androgenetic alopecia patients.

research Androgenetic Alopecia

18 citations, February 2014 in “PubMed”

Androgenetic alopecia is a common hair loss condition caused by testosterone effects on hair follicles, leading to thinner, shorter, and less pigmented hair, diagnosed using scalp dermoscopy and treated with topical minoxidil, antiandrogen agents, and 5-alpha reductase inhibitors.