The Possibilities of Correction of Premature Greying of Hair and Involutive Hair Changes

July 2024 in “ Medical alphabet ”

Е. А. Шатохина, A. V. Topskaya, Л. С. Круглова

TLDR Premature graying and hair changes can be treated with certain peptides and possibly targeting the endocannabinoid system.

The review discusses the causes and potential treatments for premature graying and hair involution. Premature graying is defined by age thresholds varying by ethnicity and is primarily driven by an imbalance between oxidative stress and the antioxidant system, with genetic factors, thyroid disorders, acute stress, and deficiencies in vitamin B12, copper, and iron also contributing. Palmitoyl tetrapeptide-20 is currently used to prevent and restore pigment loss, and the endocannabinoid system in hair follicles is being explored as a target for stimulating hair growth restoration.

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Research cited in this study

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