The Possibilities of Correction of Premature Greying of Hair and Involutive Hair Changes

July 2024 in “ Medical alphabet ”

Е. А. Шатохина, A. V. Topskaya, Л. С. Круглова

Studysummary In this review, researchers discuss the factors contributing to early graying, such as genetic predisposition, oxidative stress imbalance, and nutrient deficiencies, and highlight potential restoration methods involving palmitoyl tetrapeptide-20 and the endocannabinoid system in hair follicles. Our plain-language summary of this paper — not a Tressless recommendation.

The review discusses the causes and potential treatments for premature graying and hair involution. Premature graying is defined by age thresholds varying by ethnicity and is primarily driven by an imbalance between oxidative stress and the antioxidant system, with genetic factors, thyroid disorders, acute stress, and deficiencies in vitamin B12, copper, and iron also contributing. Palmitoyl tetrapeptide-20 is currently used to prevent and restore pigment loss, and the endocannabinoid system in hair follicles is being explored as a target for stimulating hair growth restoration.

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research Reversal of Premature Hair Graying Treated with a Topical Formulation Containing α-Melanocyte-Stimulating Hormone Agonist (Greyverse Solution 2%)

1 citations , November 2022 in “International journal of trichology”

In this case study, a 25-year-old female with premature hair graying achieved over 90% conversion of gray hair to black hair after 5 months of treatment with a topical peptide solution and hair supplements.

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3 citations , May 2022 in “Indian Journal of Dermatology”

This study found that premature hair greying may be associated with low serum ferritin and raised anti-TPO levels.

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7 citations , April 2021 in “Cannabis”

In this study, topical CBD significantly increased hair count by 93.5% over six months in individuals with androgenetic alopecia, with no adverse effects reported.

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260 citations , January 2020 in “Nature”

Stress can cause hair to turn gray by depleting stem cells.

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12 citations , September 2018 in “International Journal of Cosmetic Science”

This study demonstrated that the biomimetic peptide PTP20 may help preserve hair pigmentation and reduce greying by enhancing melanocyte function and increasing melanin production in human hair follicles.

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12 citations , May 2018 in “JAAD Case Reports”

This case report describes a patient with psoriasis who experienced scalp hair darkening and increased growth during anti–IL-17 therapy.

research Relationship Between Trace Elements and Premature Hair Graying

17 citations , January 2018 in “International Journal of Trichology”

This study found that patients with premature hair graying had lower serum levels of iron, copper, and calcium, which correlated with the severity of graying.

research Hair Repigmentation Associated With the Use of Brentuximab

15 citations , November 2017 in “JAAD Case Reports”

This study reports no known changes in hair pigmentation associated with brentuximab vedotin, despite its various other documented adverse effects.

research Demographic Characteristics and Association of Serum Vitamin B12, Ferritin, and Thyroid Function with Premature Canities in Indian Patients from an Urban Skin Clinic of North India: A Retrospective Analysis of 71 Cases

16 citations , January 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)”

This study found that premature hair graying is strongly associated with a family history, Vitamin B12 deficiency, and hypothyroidism, with onset as early as 5 years in patients in Gurugram, India.

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9 citations , July 2016 in “The Journal of Dermatology”

This letter to the editor discusses an observed case of hair repigmentation linked with etretinate therapy but reports no new research findings.

research Pigmentation of Regenerated Hairs After Wounding

16 citations , July 2016 in “Journal of Dermatological Science”

This study found that stable regeneration of pigmented hairs in mice after severe wounding can occur when the wound is made during the anagen stage, influenced by Wnt and Kit signaling pathways.

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242 citations , February 2016 in “Science”

This research found that Foxc1 transcription factor and COL17A1 are critical in regulating quiescence and hair thinning in hair follicle stem cells, with aging-related DNA damage leading to hair loss.

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17 citations , January 2015 in “Dermatology online journal”

This report describes a patient experiencing hair repigmentation linked to adalimumab therapy, a TNF inhibitor, a phenomenon not previously associated with this class of drugs.

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46 citations , April 2014 in “PLOS ONE”

This study found that compromised antioxidant activity in gray hair follicles affects both mature melanocytes and their immature precursors, linked to down-regulation of melanogenesis-related genes.

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17 citations , November 2013 in “Clinical and experimental dermatology”

This case report describes repigmentation and curling of hair in a patient undergoing acitretin therapy.

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11 citations , May 2012 in “Genesis”

This study in mutant mice found that Bmpr2 and Acvr2a are individually redundant, but together essential for normal hair follicle development, with their reduction causing rapid hair cycling and graying.

What Women Want: Quantifying the Perception of Hair Amount - An Analysis of Hair Diameter and Density Changes with Age in Caucasian Women

research What Women Want: Quantifying the Perception of Hair Amount - An Analysis of Hair Diameter and Density Changes with Age in Caucasian Women

61 citations , April 2012 in “British Journal of Dermatology”

This study analyzed changes in hair diameter and density with age in Caucasian women, highlighting variations in perception of hair amount over time.

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25 citations , March 2012 in “Journal of oncology pharmacy practice”

This case report describes an elderly multiple myeloma patient whose hair repigmentation was associated with lenalidomide use, suggesting hair graying may be reversible.

research Hair Through the Female Life Cycle

40 citations , December 2011 in “British Journal of Dermatology”

This article reviews how chronological aging affects female scalp hair growth and suggests that multiple factors, including environmental influences, contribute to female pattern hair loss; no new clinical results are presented.

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36 citations , September 2011 in “British Journal of Dermatology”

This study found that white hair exhibits increased expression of genes and proteins linked to active hair growth compared to black hair, suggesting that hair greying is associated with enhanced hair growth activity.

research Aging Processes Influence Keratin and KAP Expression in Human Hair Follicles

35 citations , May 2011 in “Experimental Dermatology”

This study found that hair follicles undergo significant molecular changes with age, notably a decline in keratins and keratin-associated proteins, which may contribute to age-related hair alterations.

research Repigmentation of Hair After Latanoprost Therapy

9 citations , December 2010 in “Journal of The European Academy of Dermatology and Venereology”

This letter reports repigmentation of hair in patients receiving latanoprost therapy.

research Investigation of Aging Effects in Human Hair Using Atomic Force Microscopy

20 citations , July 2010 in “Skin Research and Technology”

This study found that aging in Korean individuals is associated with changes in hair diameter and surface structure, as observed through atomic force microscopy.

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126 citations , January 2009 in “International Journal of Trichology”

This review discusses the potential role of oxidative stress in hair graying and age-related alopecia, emphasizing the need for new strategies to counteract these effects, but reports no new results.

Thyroid Hormones Directly Alter Human Hair Follicle Functions: Anagen Prolongation and Stimulation of Both Hair Matrix Keratinocyte Proliferation and Hair Pigmentation

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115 citations , August 2008 in “The Journal of Clinical Endocrinology & Metabolism”

In this study, T3 and T4 were found to directly influence human hair follicles in vitro, enhancing keratinocyte proliferation, prolonging the hair growth phase, and affecting pigmentation.

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23 citations , November 2007 in “Actas Dermo-Sifiliográficas”

This study suggests that topical T3 can induce hair follicles to enter the growth phase and may reverse graying in mice, with in vitro results supporting enhanced hair shaft growth.

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33 citations , July 2007 in “Skin research and technology”

The study found that the break force of human hair significantly depends on hair diameter and strain, but not on age, gender, use of hair dye, or drugs.

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76 citations , December 2006 in “Journal of Dermatological Science”

This study observed that Japanese women experience diffuse central hair loss after age 40, characterized by reduced hair density and thicker hair ratio rather than vellus-like hairs.

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210 citations , May 2006 in “The FASEB journal”

This study found that oxidative stress in hair follicle melanocytes contributes to premature aging and apoptosis, providing insights into graying as a model for studying aging and testing antiaging therapies.

research Pharmacologic Interventions in Aging Hair

80 citations , April 2006 in “Clinical Interventions in Aging”

This review discusses factors affecting hair aging and the current pharmacological treatments for androgenetic alopecia, mentioning topical minoxidil and oral finasteride, but does not present new clinical findings.

research Tyrosine Kinase Inhibition and Grey Hair

59 citations , March 2003 in “The Lancet”

Imatinib can repigment grey hair, while SU11428 can cause temporary hair depigmentation.