77 citations
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August 1986 in “Archives of Dermatology” This report describes a case in which intramuscular cyanocobalamin treatment reversed skin and nail pigmentation changes and premature gray hair caused by vitamin B12 deficiency due to pernicious anemia.
16 citations
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February 2008 in “PubMed” Vitamin B12 deficiency can cause skin darkening and white hair, but it's reversible.
16 citations
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January 2008 in “Acta dermato-venereologica” Vitamin B12 deficiency can cause skin darkening and increased blood vessels, but treatment can improve symptoms.
11 citations
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August 1986 in “Archives of Dermatology” This case report describes a patient with skin and nail hyperpigmentation and premature gray hair due to vitamin B12 deficiency, which were reversed after treatment with cyanocobalamin.
5 citations
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August 2015 in “Sultan Qaboos University medical journal” This case report highlights an atypical presentation of vitamin B12 deficiency in a 28-year-old man with reversible symptoms including localized hand hyperpigmentation and megaloblastic anemia, resolved after B12 supplementation.