Image

    Aberrant Connective Tissue Sheath Contraction Drives Premature Hair Follicle Regression by Inducing Progenitor Cell Depletion in Androgenetic Alopecia

    December 2023 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Zhili Deng, Li Yang, Shixin Duan … Ji Li

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that targeting connective tissue sheath contraction with an MLCK inhibitor may improve hair growth in androgenetic alopecia by reducing premature hair regression caused by ectopic apoptosis of hair follicle progenitor cells.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on biorxiv.org →
    Discuss this study in the Community →

    Research cited in this study 26

    1. Progenitor-Derived Endothelin Controls Dermal Sheath Contraction for Hair Follicle Regression Nature cell biology · 2023
    2. Single-Cell Transcriptomics Reveals Lineage Trajectory of Human Scalp Hair Follicle and Informs Mechanisms of Hair Graying Cell discovery · 2022
    3. Hair Follicle-Targeting Drug Delivery Strategies for the Management of Hair Follicle-Associated Disorders Asian Journal of Pharmaceutical Sciences · 2022
    4. Androgen Receptor-Mediated Paracrine Signaling Induces Regression of Blood Vessels in the Dermal Papilla in Androgenetic Alopecia Journal of Investigative Dermatology · 2022
    5. Hair Shaft Miniaturization Causes Stem Cell Depletion Through Mechanosensory Signals Mediated by a Piezo1-Calcium-TNF-α Axis Cell Stem Cell · 2021
    6. An Appraisal of Laboratory Models of Androgenetic Alopecia: A Systematic Review Skin health and disease · 2021
    7. The Inflammatory Aspect of Male and Female Pattern Hair Loss Journal of Inflammation Research · 2020
    8. Functional Complexity of Hair Follicle Stem Cell Niche and Therapeutic Targeting of Niche Dysfunction for Hair Regeneration Journal of Biomedical Science · 2020
    9. Single-Cell Transcriptomics of Traced Epidermal and Hair Follicle Stem Cells Reveals Rapid Adaptations During Wound Healing Cell Reports · 2018
    10. Genetic and Molecular Aspects of Androgenetic Alopecia Indian Journal of Dermatology, Venereology and Leprology · 2018
    11. Androgens and Androgen Receptor Action in Skin and Hair Follicles Molecular and Cellular Endocrinology · 2017
    12. The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis Journal of The American Academy of Dermatology · 2017
    13. Epithelial-Mesenchymal Micro-Niches Govern Stem Cell Lineage Choices Cell · 2017
    14. Androgenetic Alopecia: A Review Endocrine · 2017
    15. Hair Follicle Aging Is Driven by Transepidermal Elimination of Stem Cells via COL17A1 Proteolysis Science · 2016
    16. Prediction of Male-Pattern Baldness from Genotypes European Journal of Human Genetics · 2015
    17. A Guide to Studying Human Hair Follicle Cycling In Vivo Journal of Investigative Dermatology · 2015
    18. Human Hair Follicle Organ Culture: Theory, Application, and Perspectives Experimental Dermatology · 2015
    19. mTOR Signaling Promotes Stem Cell Activation via Counterbalancing BMP-Mediated Suppression During Hair Regeneration Journal of molecular cell biology/Journal of Molecular Cell Biology · 2015
    20. Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell · 2014
    21. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    22. Macroenvironmental Regulation of Hair Cycling and Collective Regenerative Behavior Cold Spring Harbor Perspectives in Medicine · 2014
    23. Androgen Actions on the Human Hair Follicle: Perspectives Experimental Dermatology · 2012
    24. New Activators and Inhibitors in the Hair Cycle Clock: Targeting Stem Cells’ State of Competence Journal of Investigative Dermatology · 2012
    25. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    26. Bald Scalp in Men with Androgenetic Alopecia Retains Hair Follicle Stem Cells but Lacks CD200-Rich and CD34-Positive Hair Follicle Progenitor Cells Journal of Clinical Investigation · 2011