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Aberrant Connective Tissue Sheath Contraction Drives Premature Hair Follicle Regression by Inducing Progenitor Cell Depletion in Androgenetic Alopecia

research Aberrant Connective Tissue Sheath Contraction Drives Premature Hair Follicle Regression by Inducing Progenitor Cell Depletion in Androgenetic Alopecia

December 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

Abnormal contraction of connective tissue in hair follicles causes hair loss by killing off important cells, and treating this could improve hair growth.

research Faculty Opinions Recommendation of Dermal Sheath Contraction Powers Stem Cell Niche Relocation During Hair Cycle Regression

March 2020 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature”

The dermal sheath's contraction is crucial for hair follicle regression and stem cell relocation.

research Hub Biomarkers in Ultrasound-Guided Bladder Cancer and Osteosarcoma: Myosin Light Chain Kinase and Caldesmon

4 citations , December 2023 in “Medicine”

Lower levels of MYLK and CALD1 in bladder cancer and osteosarcoma are linked to worse survival rates.

research A Novel Immune Competent Murine Hypertrophic Scar Contracture Model: A Tool to Elucidate Disease Mechanism and Develop New Therapies

35 citations , October 2014 in “Wound Repair and Regeneration”

The model helps understand scar contraction and develop new treatments.

research Dysregulated Behavior of Hair Follicle Stem Cells Triggers Alopecia and Provides Potential Therapeutic Targets

3 citations , May 2022 in “Experimental Dermatology”

Misbehaving hair follicle stem cells can cause hair loss and offer new treatment options.

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community Hairline stable but diffuse thinning with topical fin+min

schiz_narc_trev in Finasteride 237 upvotes 1 month ago

The user experienced stable hairline but diffuse thinning after switching from oral finasteride to a topical solution of minoxidil and finasteride. They are concerned about the effectiveness of the topical treatment and are considering other options due to a recent decline in hair density.

community The end of balding: We may have just found the secret to hair regrowth

in Technology 680 upvotes 11 months ago

MCL-1 is important for hair follicle stem cell survival, but its impact on human hair regrowth is unclear. Minoxidil and finasteride are the main treatments, with doubts about new discoveries leading to effective human solutions soon.