Causal Effects of Lipids-Related Metabolites on Androgenic Alopecia: A Mendelian Randomization Study

    February 2024 in “ Clinical, Cosmetic and Investigational Dermatology ”
    Lingbo Bi, Chaofan Wang, Yimei Du, Chuncheng Lu, Zhao Min, Yitao Ding, Weiling Sun, Weifei Fan
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    TLDR Certain fats in the blood are linked to an increased risk of male pattern baldness.
    The Mendelian randomization study, which included 119,185 participants from the Finn Gen Biobank, found a causal relationship between lipid-related metabolites and Androgenic Alopecia (AGA). The results showed that increased levels of Apolipoprotein B (ApoB), low-density lipoprotein (LDL), and very-low-density lipoprotein (VLDL) are causally related to AGA. Specifically, an increase in gene-predicted ApoB levels led to a higher risk of AGA (odds ratio (OR) = 2.288, 95% confidence interval (CI) = 1.197–4.373,p = 0.012). Similarly, an increase in LDL and VLDL particle concentration also increased the risk of AGA. The study concluded that controlling serum lipid profiles could be important in treating AGA.
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