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    Reconstructing Protein Conformations to Activate Follicular Enzyme-Nutrient Reservoirs for Reversing Follicle Aging

    May 2026 in “ Bioactive Materials ”
    Shifeng Ling, M D Liu, Chen Meng … Wenguo Cui
    Studysummary This study reported that in degenerative alopecia, Zn²⁺/Cu²⁺-dependent proteases are downregulated and destabilized, and a specially developed microneedle patch reactivated these enzymes, reduced senescence, and enhanced hair regeneration in an animal model.
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    Research cited in this study 14

    1. Hyaluronic Acid Microneedles Enhance Transdermal Delivery of Minoxidil Derivatives with 1,2,4-Oxadiazole-5-One Unit for Effective Hair Regeneration: Insights from X-Ray Crystallography and Animal Models Journal of Molecular Structure · 2025
    2. The Dual Nature of Cellular Senescence: From Aging Signature to Regenerative Catalyst Research · 2025
    3. Restoration of Follicular β-Catenin Signaling by Mesenchymal Stem Cells Promotes Hair Growth in Mice with Androgenetic Alopecia Stem Cell Research & Therapy · 2024
    4. Local and Systemic Mechanisms That Control the Hair Follicle Stem Cell Niche Nature Reviews Molecular Cell Biology · 2023
    5. Human Hair Follicle-Derived Mesenchymal Stem Cells Promote Tendon Repair in a Rabbit Achilles Tendinopathy Model Chinese Medical Journal · 2023
    6. Advances in Microneedles Research Based on Promoting Hair Regrowth Journal of Controlled Release · 2022
    7. Aging of Hair Follicle Stem Cells and Their Niches Journal of Biochemistry and Molecular Biology · 2022
    8. Microneedling for Hair Loss Journal of Cosmetic Dermatology · 2021
    9. Minoxidil: A Comprehensive Review Journal of Dermatological Treatment · 2021
    10. Functional Hair Follicle Regeneration: An Updated Review Signal Transduction and Targeted Therapy · 2021
    11. Getting Under the Skin of Hair Aging: The Impact of the Hair Follicle Environment Experimental Dermatology · 2020
    12. A Therapeutic Microneedle Patch Made from Hair-Derived Keratin for Promoting Hair Regrowth ACS nano · 2019
    13. Histopathology of Aging of the Hair Follicle Journal of Cutaneous Pathology · 2019
    14. Aging in Hair Follicle Stem Cells and Niche Microenvironment The Journal of Dermatology · 2017