Ni–Cu Bimetallic Nanozyme and Minoxidil Co-Loaded Dissolving Microneedles Reshape Hair Follicle Microenvironment for Androgenic Alopecia Treatment
April 2025
in “
OPAL (Open@LaTrobe) (La Trobe University)
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New to Minoxidil? There is a guide in the encyclopedia. Read the guide → Studysummary This study developed a dissolvable microneedle system loaded with nanozymes and minoxidil that enhanced hair regeneration in androgenetic alopecia mouse models by improving blood flow, reducing reactive oxygen species, and increasing cell proliferation compared to minoxidil alone. Our plain-language summary of this paper — not a Tressless recommendation.
The study presents a novel treatment for androgenetic alopecia (AGA) using dissolvable microneedles co-loaded with nickel–copper nanozymes and minoxidil (NC&MXD MNs). This system enhances hair follicle microenvironment by scavenging reactive oxygen species and promoting angiogenesis. In AGA mouse models, the treatment improved hair regeneration coverage to 93.7% compared to 85.1% with minoxidil alone, increased cell proliferation by 1.9-fold, and thickened hair diameter. It also reduced ROS levels by 2.3-fold and increased vascular density by 40%. The approach is safe, minimally invasive, and effective, offering a promising therapeutic strategy for AGA.
