Phase I Clinical Trial: Evaluating the Efficacy, Safety, and Patient Satisfaction of Platelet-Rich Plasma Injections and Microneedling for Androgenetic Alopecia Treatment

    September 2025 in “ Journal of Cosmetic Dermatology ”
    Mohammad Ali Nilforoushzadeh, Masoumeh Roohaninasab, Elham Behrangi … Sona Zare
    Studysummary This study found that both PRP injections and microneedling treatments significantly improved hair count and thickness in patients with androgenetic alopecia, without significant differences between the two methods. Microneedling also enhanced patient satisfaction and treatment tolerance.
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    Research cited in this study 38

    1. A Systematic Review of Case Series and Clinical Trials Investigating Regenerative Medicine for the Treatment of Vitiligo Journal of Cosmetic Dermatology · 2024
    2. Efficacy and Safety of Laser Therapy and Phototherapy in Cicatricial and Non-Cicatricial Alopecia: A Systematic Review Study Health Science Reports · 2024
    3. Regenerative Medicine in the Treatment of Specific Dermatologic Disorders: A Systematic Review of Randomized Controlled Clinical Trials Stem cell research & therapy · 2024
    4. Efficacy of Topical Minoxidil and Oral Spironolactone Versus Minoxidil and Finasteride in Androgenic Alopecia Journal of Cosmetic Dermatology · 2023
    5. Platelet Rich Plasma Application by Dermapen Microneedling and Intradermal Point-by-Point Injection Methods, and Their Comparison with Clinical Findings and Trichoscan in Patients with Androgenetic Alopecia Dermatologic Therapy · 2021
    6. Systematic Review of Platelet-Rich Plasma in Treating Alopecia: Focusing on Efficacy, Safety, and Therapeutic Durability Dermatologic Therapy · 2021
    7. Aesthetic Clinician's Guide to Platelet-Rich Plasma Springer eBooks · 2021
    8. Hair Loss Severity and Its Impact on Quality of Life in Patients Suffering from Androgenic Alopecia: A One-Year Cross-Sectional Study Clinical dermatology review · 2021
    9. Types and Treatment of Hair Loss in Men and Women Plastic and Aesthetic Nursing · 2020
    10. A Randomized Blinded Retrospective Study: The Combined Use of Micro-Needling Technique, Low-Level Laser Therapy, and Autologous Non-Activated Platelet-Rich Plasma Improves Hair Re-Growth in Patients with Androgenic Alopecia Expert Opinion on Biological Therapy · 2020
    11. Evaluation of Platelet-Rich Plasma as a Treatment for Androgenetic Alopecia: A Randomized Controlled Trial Journal of The American Academy of Dermatology · 2020
    12. The Effect of Platelet-Rich Plasma on Female Androgenetic Alopecia: A Randomized Controlled Trial Journal of The American Academy of Dermatology · 2020
    13. Platelet-Rich Plasma as a Therapy for Androgenic Alopecia: A Systematic Review and Meta-Analysis Journal of Dermatological Treatment · 2020
    14. Hair Loss and Hair Restoration in Women Facial Plastic Surgery Clinics of North America · 2020
    15. A Review of the Treatment of Male Pattern Hair Loss Expert Opinion on Pharmacotherapy · 2020
    16. Female Androgenetic Alopecia: An Update on Diagnosis and Management American Journal of Clinical Dermatology · 2019
    17. The Use of Platelet-Rich Plasma in Aesthetic and Regenerative Medicine: A Comprehensive Review Aesthetic Plastic Surgery · 2018
    18. Treatment of Male Pattern Alopecia with Platelet-Rich Plasma: A Double-Blind Controlled Study with Analysis of Platelet Number and Growth Factor Levels Journal of The American Academy of Dermatology · 2018
    19. Safety and Efficacy of Microneedling with Autologous Platelet-Rich Plasma in Chronic and Stable Alopecia Areata Journal of Pakistan Association of Dermatology · 2018
    20. Androgenetic Alopecia Treatment in Asian Men PubMed · 2018
    21. Platelet-Rich Plasma for the Treatment of Androgenic Alopecia: A Systematic Review Facial Plastic Surgery · 2018
    22. Efficacy of Non-Surgical Treatments for Androgenetic Alopecia: A Systematic Review and Network Meta-Analysis Journal of The European Academy of Dermatology and Venereology · 2018
    23. Microneedling for the Treatment of Hair Loss Journal of The European Academy of Dermatology and Venereology · 2017
    24. New-Generation Therapies for the Treatment of Hair Loss in Men Dermatologic Clinics · 2017
    25. Androgenetic Alopecia: A Review and Emerging Treatments Clinical research in dermatology · 2017
    26. Study of Gene Expression Alteration in Male Androgenetic Alopecia: Evidence of Predominant Molecular Signaling Pathways British Journal of Dermatology · 2017
    27. Androgenetic Alopecia: A Review Endocrine · 2017
    28. The Effect of Plasma Rich in Growth Factors on Pattern Hair Loss: A Pilot Study Dermatologic Surgery · 2017
    29. A Study of the Efficacy of Platelet-Rich Plasma in the Treatment of Androgenetic Alopecia in Males Indian Journal of Dermatology, Venereology and Leprology · 2016
    30. A Mechanistic Model of Platelet-Rich Plasma Treatment for Androgenetic Alopecia Dermatologic Surgery · 2016
    31. Differential Expression Between Human Dermal Papilla Cells from Balding and Non-Balding Scalps Reveals New Candidate Genes for Androgenetic Alopecia Journal of Investigative Dermatology · 2016
    32. Microneedling as a Successful Treatment for Alopecia X in Two Pomeranian Siblings Veterinary Dermatology · 2015
    33. Androgenetic Alopecia: An Evidence-Based Treatment Update American Journal of Clinical Dermatology · 2014
    34. Exogenous IGF-1 Promotes Hair Growth by Stimulating Cell Proliferation and Downregulating TGF-β1 in C57BL/6 Mice In Vivo Growth Hormone & IGF Research · 2014
    35. Insulin-Like Growth Factor-1: Roles in Androgenetic Alopecia Experimental Dermatology · 2014
    36. Alopecia Areata: Successful Outcome with Microneedling and Triamcinolone Acetonide Journal of Cutaneous and Aesthetic Surgery · 2014
    37. A Randomized Evaluator Blinded Study of Effect of Microneedling in Androgenetic Alopecia: A Pilot Study International Journal of Trichology · 2013
    38. PDGF Isoforms Induce and Maintain Anagen Phase of Murine Hair Follicles Journal of Dermatological Science · 2006

    Related research 6

    1. Hair Loss Pharmacy Today · 2021
    2. Hair Loss: Causes and Pathology International Journal of Research in Medical Sciences & Technology · 2021
    3. Diffuse Hair Loss Elsevier eBooks · 2021
    4. Platelet-Rich Plasma Effect on Androgenetic Alopecia and Female Pattern Hair Loss Journal of skin and stem cell · 2019
    5. Comparison of the Efficacy of Homologous and Autologous Platelet-Rich Plasma for Treating Androgenic Alopecia Aesthetic Plastic Surgery · 2017
    6. A Review on Hair Loss and Damage 2016