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    Recent Advances in the Genetics of Alopecia Areata

    April 2023 in “ Medizinische Genetik ”
    F. Buket Basmanav, Regina C. Betz
    Studysummary This review summarizes recent genetic findings in alopecia areata research and their implications for developing new treatments, without reporting new clinical results.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 36

    1. Whole Exome Sequencing in Alopecia Areata Identifies Rare Variants in KRT82 Nature communications · 2022
    2. Ritlecitinib And Brepocitinib Demonstrate Significant Improvement In Scalp Alopecia Areata Biomarkers ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2021
    3. Alopecia Areata Treatment Patterns, Healthcare Resource Utilization, and Comorbidities in the US Population Using Insurance Claims Advances in Therapy · 2021
    4. Efficacy and Safety of the Oral Janus Kinase Inhibitor Baricitinib in the Treatment of Adults with Alopecia Areata: Phase 2 Results from a Randomized Controlled Study Journal of The American Academy of Dermatology · 2021
    5. A Comprehensive Literature Review of JAK Inhibitors in the Treatment of Alopecia Areata Clinical, cosmetic and investigational dermatology · 2021
    6. Hair Follicle Immune Privilege and Its Collapse in Alopecia Areata Experimental dermatology · 2020
    7. A Transcriptomic Map of Murine and Human Alopecia Areata JCI Insight · 2020
    8. JAK Inhibition in the Treatment of Alopecia Areata: A Promising New Dawn? Expert review of clinical pharmacology · 2019
    9. IL-12/IL-23 Neutralization Is Ineffective for Alopecia Areata in Mice and Humans ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2019
    10. Integrative Analysis of Rare Copy Number Variants and Gene Expression Data in Alopecia Areata Implicates an Etiological Role for Autophagy Experimental Dermatology · 2019
    11. Alopecia Areata Is Characterized by Dysregulation in Systemic Type 17 and Type 2 Cytokines, Which May Contribute to Disease-Associated Psychological Morbidity British journal of dermatology/British journal of dermatology, Supplement · 2019
    12. JAK Inhibitors for Alopecia Areata: A Systematic Review and Meta-Analysis JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2019
    13. JAK Inhibitors and Alopecia Areata Lancet · 2019
    14. A Randomized Placebo-Controlled Single-Center Pilot Study of the Safety and Efficacy of Apremilast in Subjects with Moderate-to-Severe Alopecia Areata Archives of dermatological research · 2018
    15. Dermatological Aspects of the S2k Guidelines on Down Syndrome in Childhood and Adolescence JDDG Journal der Deutschen Dermatologischen Gesellschaft · 2018
    16. An Integrated Model of Alopecia Areata Biomarkers Highlights Both TH1 and TH2 Upregulation Journal of Allergy and Clinical Immunology · 2018
    17. An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis Journal of Investigative Dermatology · 2018
    18. Novel Therapies for Alopecia Areata: The Era of Rational Drug Development The Journal of Allergy and Clinical Immunology · 2017
    19. Hair Follicle Immune Privilege Revisited: The Key to Alopecia Areata Management ˜The œjournal of investigative dermatology. Symposium proceedings/˜The œJournal of investigative dermatology symposium proceedings · 2017
    20. Safety and Efficacy of the JAK Inhibitor Tofacitinib Citrate in Patients with Alopecia Areata JCI insight · 2016
    21. Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata JCI insight · 2016
    22. Genomewide Analysis of Copy Number Variants in Alopecia Areata in a Central European Cohort Reveals Association with MCHR2 Experimental Dermatology · 2016
    23. Familial Aggregation of Alopecia Areata Journal of the American Academy of Dermatology · 2016
    24. ULBP3: A Marker for Alopecia Areata Incognita Archives of Dermatological Research · 2016
    25. Biomarkers of Alopecia Areata Disease Activity and Response to Corticosteroid Treatment Experimental dermatology · 2015
    26. Alopecia Areata Profiling Shows TH1, TH2, and IL-23 Cytokine Activation Without Parallel TH17/TH22 Skewing ˆThe ‰journal of allergy and clinical immunology/Journal of allergy and clinical immunology/˜The œjournal of allergy and clinical immunology · 2015
    27. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    28. Exomic Sequencing of Immune-Related Genes Reveals Novel Candidate Variants Associated with Alopecia Universalis PLoS ONE · 2013
    29. Unveiling the Roots of Monogenic Genodermatoses: Genotrichoses as a Paradigm Journal of Investigative Dermatology · 2011
    30. Transcriptional Profiling in Alopecia Areata Defines Immune and Cell Cycle Control Related Genes Within Disease-Specific Signatures Genomics · 2010
    31. Genome-Wide Association Study in Alopecia Areata Implicates Both Innate and Adaptive Immunity Nature · 2010
    32. Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007
    33. Hair Follicle-Specific Keratins And Their Diseases Experimental cell research · 2007
    34. Genomewide Scan for Linkage Reveals Evidence of Several Susceptibility Loci for Alopecia Areata The American Journal of Human Genetics · 2007
    35. Autoimmunity: Alopecia Areata Journal of Investigative Dermatology Symposium Proceedings · 2004
    36. Gene Array Profiling and Immunomodulation Studies Define a Cell-Mediated Immune Response Underlying the Pathogenesis of Alopecia Areata in a Mouse Model and Humans Journal of Investigative Dermatology · 2002

    Related research 8

    1. Recent Advances in the Genetics of Alopecia Areata Medizinische Genetik · 2023
    2. Alopecia Areata: The Disease of Hairless Patches on the Scalp and Any Area of Face Journal of pharmaceutical negative results · 2022
    3. Efficacy of Systemic Minoxidil and Tofacitinib Combination in Treatment-Resistant Alopecia Universalis Journal of Cosmetic Dermatology · 2020
    4. Alopecia Areata: A Non-Scarring, Multifocal Hair Growth Disorder Harper's Textbook of Pediatric Dermatology · 2011
    5. Alopecia Areata: Clinical Presentation, Diagnosis, and Unusual Cases Dermatologic Therapy · 2011
    6. Diagnosis of Hair Loss: Clinical Features of Common Causes PubMed · 1992
    7. Diagnosis and Management of the Hair Loss Patient PubMed · 1987
    8. PUVA Therapy for Alopecia Areata 1981