Hair Aging Revisited: An Expert Delphi Consensus on Pathogenesis, Clinical Features, and Future Therapies

This study presents male pattern androgenetic alopecia (mpAGA) as a natural physiological process involving reversible transformation of hair follicles, but notes unresolved links with androgen mechanisms and highlights potential research avenues beyond androgen receptor signaling for treatment exploration.

Topical minoxidil effectively stimulates hair growth in men with hair loss.

In this case study, a patient experienced darkening of hair color after taking acitretin, an oral retinoid known for potentially causing alopecia, marking a rare and undocumented phenomenon.

This study highlights multiple factors contributing to hair graying, such as oxidative damage, melanocyte changes, and genetic influences, and suggests that repigmentation may be temporarily reversible, offering potential targets for future treatments while urging caution when applying mouse model findings to humans.

This study found that ITGA6-positive dermal sheath cup cells, identified by their superior migratory activity, may enhance cell-based therapy for male and female pattern hair loss by promoting cell migration into hair follicles.

In this study, researchers found that exosomes derived from dermal sheath cup cells (Exo DSCCs) improved proliferation, viability, and migration while reducing apoptosis in senescent dermal papilla cells, also enhancing hair follicle reconstruction and suggesting a potential strategy for combating senile alopecia.

Minoxidil and platelet-rich plasma can help turn thin hair into thicker hair in male pattern baldness.

In this viewpoint, researchers discussed the possible role of the developmental origin of scalp dermis in influencing the specific pattern of hair follicle miniaturization seen in male pattern hair loss, noting that frontal follicles are more susceptible while occipital follicles remain largely terminal.

This review discusses the mechanisms of hair repigmentation and reports no clinical results; the authors suggest further research into topical treatments for reversing gray hair.

This review discusses the potential of secretome derived from stem cells for treating alopecia areata and reports no new clinical results; the authors suggest the need for further human trials.

This study found that mitochondrial dysfunction and higher oxidative stress in balding dermal papilla cells may contribute to androgenetic alopecia, with antioxidants potentially improving metabolite uptake.

This study observed that aging leads to significant structural and biological changes in the scalp's hair follicle environment in women, which may affect hair growth.

This preclinical study observed that a nanoencapsulated ingredient complex, AcPi, may prevent hair follicle aging and hair loss by reducing oxidative stress, enhancing mitochondrial activity and WNT/β-catenin signaling, and controlling androgenic metabolism when tested on human scalp cultures.

This review discusses premature graying of hair, highlighting risk factors like smoking and vitamin deficiencies, and suggests that addressing underlying conditions may reverse the graying process.

This study found that genetically variant peptides from human hair can reliably identify individuals despite differences in age and storage conditions, provided environmental and processing factors are controlled.

This review discusses age-related changes in scalp skin and their potential effects on hair follicle aging, but reports no new clinical results, calling for further investigation.

This study found that injecting autologous dermal sheath cup cells significantly increased hair density and diameter in male and female pattern hair loss compared to a placebo for up to 9 months.

This review discusses medication-induced gray hair repigmentation, highlighting that certain anti-inflammatory drugs and melanogenesis stimulators can cause diffuse repigmentation, though evidence remains low-quality and these medications are not currently indicated for this purpose.

This review discusses the impact of age-related hair changes on perceived attractiveness and self-perception, emphasizing the need for holistic anti-aging consultations that include hair preservation strategies.

This study suggests that down-regulation of vasculature-related genes in dermal papilla cells from balding scalps might contribute to the development of androgenetic alopecia.

This study found that sulforaphane treatment enhanced hair regeneration in ob/ob mice by increasing DHT-degrading enzyme levels and lowering plasma testosterone and DHT.

This study found that a 6-month supplementation with omega 3, omega 6, and antioxidants significantly improved hair density and reduced hair loss in women with female pattern hair loss.

The conclusion is that androgenetic alopecia and senescent alopecia have unique gene changes, suggesting different causes and potential treatments for these hair loss types.

This study analyzed changes in hair diameter and density with age in Caucasian women, highlighting variations in perception of hair amount over time.

In this study, old age was concluded not to be a significant cause of hair loss, with most cases in the elderly appearing to be androgen-driven.

This study found that aging in Korean individuals is associated with changes in hair diameter and surface structure, as observed through atomic force microscopy.

This study found that hair luster decreases with age in Japanese females, primarily due to an irregular increase in fiber curvature which affects hair alignment.

This study found that hydrogen peroxide accumulation and reduced methionine sulfoxide repair play a significant role in the oxidative damage linked to senile hair graying.

This review discusses the mechanisms by which sunlight exposure aggravates hair aging and highlights the role of hair pigments in providing photochemical protection, reporting no new results.

This review examines the differential aging of melanocytes in hair follicles and skin, and reports no new findings; the authors suggest further research is needed to understand these processes.

This study examined hair curvature in Japanese women, finding that 47% have curved hair, and identified structural differences in hair fiber, which resemble those in wool fibers.

This review discusses the biological and cosmetic aspects of hair aging and reports no new clinical results; it highlights current treatments and future research directions to address both aging factors.

This study found that oxidative stress in hair follicle melanocytes contributes to premature aging and apoptosis, providing insights into graying as a model for studying aging and testing antiaging therapies.

This review discusses factors affecting hair aging and the current pharmacological treatments for androgenetic alopecia, mentioning topical minoxidil and oral finasteride, but does not present new clinical findings.

This article reviews factors influencing hair aging and available treatments like minoxidil and finasteride for androgenetic alopecia but reports no new clinical results.

This study found that age and follicular miniaturization were extremely weak predictors of total hair count in women with hair loss.

This review discusses the relationship between perceived stress and hair loss or graying, exploring hair follicles as a model system but reports no new clinical results.

This review discusses the histopathology of male-pattern baldness and highlights ongoing disputes over several aspects, including sebaceous gland size and follicle loss, reporting no new clinical findings.