Image

    Minoxidil Downregulates Interleukin-1 Alpha Gene Expression in HaCaT Cells

    January 2018 in “ International Journal of Trichology ”
    Erkin Pekmezci, Murat Türkoğlu, Hilal Gökalp, Zekayі Kutlubay
    Studysummary In this study, minoxidil significantly downregulated interleukin-1 alpha expression in human keratinocyte cells, suggesting an anti-inflammatory effect that may be a mechanism of action in treating alopecia.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
    Read the full study on ijtrichology.com →
    Discuss this study in the Community →

    Research cited in this study 27

    1. Novel Enzymatic Assay Predicts Minoxidil Response in the Treatment of Androgenetic Alopecia Dermatologic Therapy · 2013
    2. Oxidative Stress in Alopecia Areata: A Case-Control Study American Journal of Clinical Dermatology · 2013
    3. The Role of Inflammation and Immunity in the Pathogenesis of Androgenetic Alopecia PubMed · 2011
    4. Male Androgenetic Alopecia Expert Opinion on Pharmacotherapy · 2010
    5. Androgenetic Alopecia in Males: A Histopathological and Ultrastructural Study Journal of Cosmetic Dermatology · 2009
    6. Human Hair Follicles Contain Two Forms of ATP-Sensitive Potassium Channels, Only One Sensitive to Minoxidil The FASEB Journal · 2008
    7. A Multicenter, Randomized, Placebo-Controlled, Double-Blind Clinical Trial of a Novel Formulation of 5% Minoxidil Topical Foam Versus Placebo in the Treatment of Androgenetic Alopecia in Men Journal of The American Academy of Dermatology · 2007
    8. Obesity and Low-Grade Inflammation Among Young Finnish Men With Early-Onset Alopecia Dermatology · 2007
    9. The Additive Effects of Minoxidil and Retinol on Human Hair Growth In Vitro Biological & Pharmaceutical Bulletin · 2007
    10. Influence of Interleukin-1α on Androgen Receptor Expression and Cytokine Secretion by Cultured Human Dermal Papilla Cells Experimental Dermatology · 2006
    11. Novel and Established Potassium Channel Openers Stimulate Hair Growth In Vitro: Implications for Their Modes of Action in Hair Follicles Journal of Investigative Dermatology · 2005
    12. Minoxidil: Mechanisms of Action on Hair Growth British Journal of Dermatology · 2004
    13. Molecular Mechanisms of Androgenetic Alopecia Experimental Gerontology · 2002
    14. Minoxidil Upregulates the Expression of Vascular Endothelial Growth Factor in Human Hair Dermal Papilla Cells British Journal of Dermatology · 1998
    15. Interleukin-1β-Induced Inhibition of Hair Growth In Vitro Is Mediated by Cyclic AMP Journal of Investigative Dermatology · 1997
    16. Dermal-Epidermal Interactions in Hair Follicle Development and Maintenance Dermatologic clinics · 1996
    17. Cytokines and Growth Factors Influence Hair Growth In Vitro: Possible Implications for the Pathogenesis and Treatment of Alopecia Areata Archives of Dermatological Research · 1996
    18. Molecular Approach of Hair Biology PubMed · 1994
    19. IL-1 Alpha Inhibits Human Hair Follicle Growth And Hair Fiber Production In Whole-Organ Cultures PubMed · 1993
    20. Potassium Channel Conductance as a Control Mechanism in Hair Follicles Journal of Investigative Dermatology · 1993
    21. Potassium Channel Conductance as a Control Mechanism in Hair Follicles Journal of Investigative Dermatology · 1993
    22. Potassium Channel Conductance: A Mechanism Affecting Hair Growth Both In Vitro and In Vivo Journal of Investigative Dermatology · 1992
    23. Minoxidil Sulfate Is the Active Metabolite That Stimulates Hair Follicles Journal of Investigative Dermatology · 1990
    24. Potential Mechanisms of Minoxidil-Induced Hair Growth in Alopecia Areata Journal of the American Academy of Dermatology · 1987
    25. Minoxidil Stimulates Cutaneous Blood Flow in Human Balding Scalps: Pharmacodynamics Measured by Laser Doppler Velocimetry and Photopulse Plethysmography Journal of Investigative Dermatology · 1984
    26. Direct Effects of Minoxidil on Epidermal Cells in Culture Journal of Investigative Dermatology · 1984
    27. Effect of Minoxidil on Cultured Keratinocytes Journal of Investigative Dermatology · 1983