BLIMP1 Is Required for Postnatal Epidermal Homeostasis but Does Not Define a Sebaceous Gland Progenitor Under Steady-State Conditions

September 2014 in “ Stem cell reports ”

Kai Kretzschmar, Denny L. Cottle, Giacomo Donati, Ming-Feng Chiang, Sven R Quist, Harald Gollnick, Ken Natsuga, Kuo‐I Lin, Fiona M. Watt

BLIMP1 epidermis sebaceous gland hair follicle c-Myc androgen signaling differentiation defects sebocytes lineage-tracing homeostasis skin oil gland hair root Myc hormone signaling cell differentiation oil-producing cells cell tracking balance

Studysummary In this study, BLIMP1 was found to function in terminally differentiated epidermal cells to maintain homeostasis, rather than defining a sebocyte progenitor population.

Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer

View this study on cell.com →

Discuss this study in the Community →

Research cited in this study

14 / 14 results

research Markers of Epidermal Stem Cell Subpopulations in Adult Mammalian Skin

96 citations , July 2014 in “Cold Spring Harbor Perspectives in Medicine”

This review discusses various stem cell compartments in adult murine and human epidermis, examining their expressed markers and characterization assays, and reports no new experimental results.

research Plasticity of Epithelial Stem Cells in Tissue Regeneration

479 citations , June 2014 in “Science”

This review discusses the plasticity of epithelial stem cells in regenerative contexts and reports no new research findings; the authors highlight potential implications for regenerative medicine and cancer.

research Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair

1235 citations , December 2013 in “Nature”

This study found that skin fibroblasts in mice arise from two distinct lineages which contribute differently to dermal structure and repair, impacting hair follicle formation during wound healing.

research Regenerating the Skin: A Task for the Heterogeneous Stem Cell Pool and Surrounding Niche

133 citations , September 2013 in “Nature Reviews Molecular Cell Biology”

Different types of stem cells and their environments are key to skin repair and maintenance.

research C-MYC-Induced Sebaceous Gland Differentiation Is Controlled by an Androgen Receptor/p53 Axis

60 citations , February 2013 in “Cell reports”

This study demonstrates that c-MYC overexpression in sebaceous glands affects differentiation via a regulatory axis involving the androgen receptor and p53, influencing carcinoma formation outcomes.

research Development and Homeostasis of the Sebaceous Gland

107 citations , August 2012 in “Seminars in Cell & Developmental Biology”

This review discusses the role of signaling networks in sebaceous gland development and disorders, highlighting recent insights from mouse models and cell line studies, but reports no new experimental results.

research C/EBPα and C/EBPβ Are Required for Sebocyte Differentiation and Stratified Squamous Differentiation in Adult Mouse Skin

48 citations , March 2010 in “PloS one”

This study found that the co-ablation of C/EBPalpha and C/EBPbeta in adult mouse skin disrupted sebocyte differentiation and epidermal homeostasis, highlighting their critical roles in these processes.

research Epidermal Stem Cell Diversity and Quiescence

168 citations , August 2009 in “EMBO molecular medicine”

This review discusses epidermal stem cell diversity, revealing previously unrecognized differences in stem cell populations, but reports no new experimental results; it highlights the need for further exploration of stem cell interactions and quiescence.

research Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis

503 citations , May 2009 in “Cell stem cell”

This study suggests that Lrig1-positive cells form a previously unknown reservoir of interfollicular epidermal stem cells in adult mouse skin, influencing epidermal proliferation and hair follicle development.

research Dynamic Regulation of Retinoic Acid-Binding Proteins in Developing, Adult, and Neoplastic Skin Reveals Roles for β-Catenin and Notch Signaling

84 citations , September 2008 in “Developmental biology”

This study found that cellular retinoic acid-binding proteins and fatty acid-binding proteins are dynamically expressed in skin development and respond differently to retinoic acid, β-catenin, and Notch signaling.

research Manipulation of Stem Cell Proliferation and Lineage Commitment: Visualization of Label-Retaining Cells in Wholemounts of Mouse Epidermis

421 citations , September 2003 in “Development”

This study concluded that label-retaining cells in mouse epidermis differ in their sensitivity to proliferative stimuli, influencing their division and potential transdifferentiation without consistently depleting their population.

research Expression of ΔNLef1 in Mouse Epidermis Results in Differentiation of Hair Follicles into Squamous Epidermal Cysts and Formation of Skin Tumors

297 citations , January 2002 in “Development”

In this study, repressing β-catenin/Lef1 signalling in mouse epidermis led to progressive hair loss, dermal cysts, and spontaneous skin tumors with sebaceous differentiation, indicating altered keratinocyte differentiation and potential tumourigenic processes.

research C-Myc Activation in Transgenic Mouse Epidermis Results in Mobilization of Stem Cells and Differentiation of Their Progeny

338 citations , April 2001 in “Current Biology”

This study found that transient activation of c-Myc in transgenic mice stimulates keratinocyte proliferation and sebocyte differentiation, affecting normal epidermal and hair follicle development.

research Expression of Keratin K14 in the Epidermis and Hair Follicle: Insights Into Complex Programs of Differentiation

198 citations , November 1989 in “The Journal of Cell Biology”

This study reported that K14 expression patterns and keratin filament organization in human skin's hair follicles differ from those in the epidermis, indicating distinct differentiation programs.