Synergistic Effects of Mesenchymal Stem Cell Secretome and Wnt10b on Hair Follicle Regeneration in a 3D Bioengineering Model: A Preclinical Study

    November 2025 in “ Stem Cell Research & Therapy ”
    Amir Bajouri, Nasser Aghdami, Mohammad Ali Nilforoushzadeh
    Studysummary In this study, the authors reported that combining PMSC-secretome and Wnt10b in a GelMA hydrogel scaffold promoted effective hair follicle biofabrication and hair growth in a small in vivo experiment. They emphasized the need for larger studies to confirm these results.
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    Research cited in this study 27

    1. Therapeutic Potential of Stem Cell-Derived Exosomes in Hair Regeneration: A Systematic Review World Journal of Stem Cells · 2025
    2. CD133 Defines Hair-Inductive Cells in the Dermal Papilla Scientific Reports · 2025
    3. Wnt10b Regulation of Hair Follicle Development, Regeneration, and Skin Diseases Stem Cell Reviews and Reports · 2025
    4. Exploring Mesenchymal Stem Cells Versus Minoxidil for Androgenic Alopecia Treatment: A Detailed Animal-Based Histological and Morphometric Study Cells Tissues Organs · 2024
    5. Immune Niches for Hair Follicle Development and Homeostasis Frontiers in physiology · 2024
    6. Incorporation of Hair Follicles in 3D Bioprinted Models of Human Skin Science Advances · 2023
    7. In Vitro Hair Follicle Growth Model for Drug Testing Scientific Reports · 2023
    8. Integrating Zinc/Silicon Dual Ions With 3D-Printed GelMA Hydrogel Promotes In Situ Hair Follicle Regeneration International Journal of bioprinting · 2023
    9. Expansion Culture of Hair Follicle Stem Cells Through Uniform Aggregation in Microwell Array Devices ACS Biomaterials Science & Engineering · 2023
    10. Hair Regrowth Treatment Efficacy and Resistance in Androgenetic Alopecia: A Systematic Review and Continuous Bayesian Network Meta-Analysis Frontiers in Medicine · 2023
    11. Stem Cell Secretome as a Mechanism for Restoring Hair Loss Due to Stress, Particularly Alopecia Areata: Narrative Review Journal of Biomedical Science · 2022
    12. 3D Printing of Skin Equivalents with Hair Follicle Structures and Epidermal-Papillary-Dermal Layers Using Gelatin/Hyaluronic Acid Hydrogels Chemistry - an Asian journal · 2022
    13. 3D Bioprinting of a Gelatin-Alginate Hydrogel for Tissue-Engineered Hair Follicle Regeneration Acta Biomaterialia · 2022
    14. Evaluation of Serum Levels of IL-6, IL-10, and TNF-a in Alopecia Areata Patients: A Systematic Review and Meta-Analysis Biomedical Research and Therapy · 2021
    15. Biomechanics of Hair Fiber Growth: A Multi-Scale Modeling Approach Journal of the mechanics and physics of solids/Journal of the Mechanics and Physics of Solids · 2021
    16. The Microfollicle: A Model of the Human Hair Follicle for In Vitro Studies In Vitro Cellular & Developmental Biology - Animal · 2020
    17. Tissue Engineering Strategies for Human Hair Follicle Regeneration: How Far From a Hairy Goal? Stem Cells Translational Medicine · 2019
    18. Overexpression of Alkaline Phosphatase Improves the Hair-Inductive Capacity of Cultured Human Dermal Papilla Spheres Journal of Dermatological Science · 2019
    19. Tissue Engineering of Human Hair Follicles Using a Biomimetic Developmental Approach Nature Communications · 2018
    20. Immunohistochemical Study of Hair Follicle Stem Cells in Regenerated Hair Follicles Induced by Wnt10b International Journal of Medical Sciences · 2016
    21. Hair Restoration Surgery: Challenges and Solutions Clinical, Cosmetic and Investigational Dermatology · 2015
    22. The Dermal Papilla: An Instructive Niche for Epithelial Stem and Progenitor Cells in Development and Regeneration of the Hair Follicle Cold Spring Harbor Perspectives in Medicine · 2014
    23. Keratin K15 as a Biomarker of Epidermal Stem Cells International Journal of Molecular Sciences · 2013
    24. Dissociated Human Dermal Papilla Cells Induce Hair Follicle Neogenesis in Grafted Dermal-Epidermal Composites Journal of Investigative Dermatology · 2013
    25. Fully Functional Hair Follicle Regeneration Through the Rearrangement of Stem Cells and Their Niches Nature Communications · 2012
    26. Review of Hair Follicle Dermal Cells Journal of Dermatological Science · 2009
    27. The Mesenchymal Component of Hair Follicle Neogenesis: Background, Methods, and Molecular Characterization Experimental Dermatology · 2009