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    Smurf2-Induced Degradation of SMAD2 Causes Inhibition of Hair Follicle Stem Cell Differentiation

    April 2022 in “ Cell Death Discovery ”
    Bojie Lin, Dan Huang, Guanyu Lin … Zhiqi Hu
    Studysummary This study found that SMAD2 overexpression in human hair follicle stem cells promoted differentiation and apoptosis while inhibiting proliferation, and Smurf2 upregulation limited mouse wound healing by suppressing the SMAD2/NANOG/DNMT1 axis.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 11

    1. Effects of Hair Follicle Stem Cells on Partial-Thickness Burn Wound Healing and Tensile Strength Iranian Biomedical Journal · 2019
    2. BMP2-Mediated PTEN Enhancement Promotes Differentiation of Hair Follicle Stem Cells by Inducing Autophagy Experimental cell research · 2019
    3. PBX Homeobox 1 Enhances Hair Follicle Mesenchymal Stem Cell Proliferation and Reprogramming Through Activation of the AKT/Glycogen Synthase Kinase Signaling Pathway and Suppression of Apoptosis Stem Cell Research & Therapy · 2019
    4. Are Hair Follicle Stem Cells Promising Candidates for Wound Healing? Expert Opinion on Biological Therapy · 2018
    5. Engineered Hair Follicle Mesenchymal Stem Cells Overexpressing Controlled-Release Insulin Reverse Hyperglycemia in Mice with Type 1 Diabetes Cell transplantation · 2014
    6. Generation of Folliculogenic Human Epithelial Stem Cells from Induced Pluripotent Stem Cells Nature communications · 2014
    7. Epithelial Stem Cells And Implications For Wound Repair Seminars in Cell & Developmental Biology · 2012
    8. Paracrine TGF-β Signaling Counterbalances BMP-Mediated Repression in Hair Follicle Stem Cell Activation Cell stem cell · 2012
    9. The Multipotency of Adult Vibrissa Follicle Stem Cells Differentiation · 2009
    10. Stem Cells in the Hair Follicle Bulge Contribute to Wound Repair but Not to Homeostasis of the Epidermis Nature Medicine · 2005
    11. Multipotent Nestin-Positive, Keratin-Negative Hair-Follicle Bulge Stem Cells Can Form Neurons Proceedings of the National Academy of Sciences · 2005