Understanding the Molecular Landscape of Alopecia Areata: Key Genes, Regulatory Networks, and Therapeutic Targets

    June 2026 in “ Health Science Reports ”
    Ahmed Ibrahim AbdElneam, Mohammed Saleh Al‐Dhubaibi, Saleh Salem Bahaj … Lina Mohammed Atef
    Studysummary This study examined the genetic basis of alopecia areata by analyzing gene expression differences between patients and healthy controls, identifying critical pathways, hub genes, transcription factors, and miRNAs implicated in the disease, and suggesting potential targets for treatment.
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    Research cited in this study 18

    1. Regulatory T Cells in Skin Mediate Immune Privilege of the Hair Follicle Stem Cell Niche Science Immunology · 2024
    2. Lifestyle Factors Involved in the Pathogenesis of Alopecia Areata International journal of molecular sciences · 2022
    3. Perspectives on MicroRNAs Targeting DKK1 for Developing Hair Regeneration Therapy Cells · 2021
    4. Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
    5. Current Insight Into the Functions of MicroRNAs in Common Human Hair Loss Disorders: A Mini Review Human Cell · 2021
    6. Alopecia Areata Patients Show Deficiency of FOXP3+CD39+ T Regulatory Cells and Clonotypic Restriction of Treg TCRβ-Chain, Highlighting the Immunopathological Aspect of the Disease PloS one · 2019
    7. Regulatory T-Cells in Alopecia Areata Journal of cutaneous pathology · 2019
    8. Identification of Blood MicroRNA Alterations in Patients With Severe Active Alopecia Areata Journal of Cellular Biochemistry · 2019
    9. Study of Skin Expression of MicroRNA-146a in Patients with Alopecia Areata Benha Journal of Applied Sciences · 2018
    10. An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis Journal of Investigative Dermatology · 2018
    11. Identification of Differentially Expressed miRNAs in Alopecia Areata That Target Immune-Regulatory Pathways Genes and immunity · 2017
    12. The Role of Lymphocytes in the Development and Treatment of Alopecia Areata Expert Review of Clinical Immunology · 2015
    13. The Autoimmune Basis of Alopecia Areata: A Comprehensive Review Autoimmunity reviews · 2014
    14. Transcriptional Profiling in Alopecia Areata Defines Immune and Cell Cycle Control Related Genes Within Disease-Specific Signatures Genomics · 2010
    15. Controlled Delivery of T-box21 Small Interfering RNA Ameliorates Autoimmune Alopecia in a C3H/HeJ Mouse Model ˜The œAmerican journal of pathology · 2008
    16. Human Leukocyte Antigen Class II Alleles Are Associated with Risk of Alopecia Areata Journal of Investigative Dermatology · 2007
    17. Selective Expression of Chemokine Monokine Induced by Interferon-γ in Alopecia Areata Journal of Investigative Dermatology · 2003
    18. Alopecia Areata in Korea (1982–1994) The Journal of Dermatology · 1995