Performance Exploration of Multi-Gene Panels of Alopecia Areata Susceptibility and Drug-Binding Targets

    March 2025 in “ Frontiers in Physiology ”
    Hongye Liu, Yang Li, Ling Ren … Shuping Guo
    Studysummary This study identified key genes linked to immune cells and potential therapeutic compounds for alopecia areata by evaluating upregulated genes from patient datasets, highlighting T and NK cell involvement in hair follicle attack and suggesting drug candidates through molecular docking and dynamics simulations.
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    Research cited in this study 16

    1. Functional Interrogation of Lymphocyte Subsets in Alopecia Areata Using Single-Cell RNA Sequencing Proceedings of the National Academy of Sciences · 2023
    2. Novel Potential Therapeutic Targets of Alopecia Areata Frontiers in Immunology · 2023
    3. Efficacy of a Mixed Preparation Containing Piperine, Capsaicin, and Curcumin in the Treatment of Alopecia Areata Journal of cosmetic dermatology · 2022
    4. Alopecia Areata: An Update on Etiopathogenesis, Diagnosis, and Management Clinical Reviews in Allergy & Immunology · 2021
    5. Pro-Inflammatory Vδ1+ T-Cells Infiltrates Are Present In And Around The Hair Bulbs Of Non-Lesional And Lesional Alopecia Areata Hair Follicles Journal of Dermatological Science · 2020
    6. Pathomechanisms of Immune-Mediated Alopecia International Immunology · 2019
    7. Regulatory T-Cells in Alopecia Areata Journal of cutaneous pathology · 2019
    8. JAK Inhibitors for Alopecia Areata: A Systematic Review and Meta-Analysis JEADV. Journal of the European Academy of Dermatology and Venereology/Journal of the European Academy of Dermatology and Venereology · 2019
    9. iNKT Cells Ameliorate Human Autoimmunity: Lessons from Alopecia Areata Journal of autoimmunity · 2018
    10. Alopecia Areata: Treatment Options and Efficacy Journal of the American Academy of Dermatology · 2017
    11. Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata JCI insight · 2016
    12. Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition Nature medicine · 2014
    13. Efficacy and Tolerability of Methotrexate in Severe Childhood Alopecia Areata British journal of dermatology/British journal of dermatology, Supplement · 2011
    14. Maintenance of Hair Follicle Immune Privilege Is Linked to Prevention of NK Cell Attack Journal of Investigative Dermatology · 2007
    15. The Pattern and Profile of Alopecia Areata in Singapore: A Study of 219 Asians International Journal of Dermatology · 2002
    16. Topical Minoxidil (3%) in Extensive Alopecia Areata, Including Long-Term Efficacy Journal of The American Academy of Dermatology · 1987

    Related research 1

    1. Serum Zinc Concentration in Patients With Alopecia Areata Acta dermato-venereologica (Print) · 2023