Identification of Key Genes and Signaling Pathways in Male Androgenetic Alopecia by Bioinformatics Analysis

July 2020 in “ Bioinformatics and Bioengineering ”

Mengzhi Zhang, Yu-Jia Chen, Liancheng Guan, Wei Li, Yunzhi Chen

androgenetic alopecia immune response hair growth cycle epidermal development bioinformatics analysis differentially expressed genes MAGA inflammatory responses male pattern baldness hair growth skin development

TLDR Found key genes affecting hair loss, immune response, and skin development; more research needed for better treatments.

The study used bioinformatics analysis to identify key genes and signaling pathways in male androgenetic alopecia (MAGA). The analysis found 214 differentially expressed genes, with up-regulated genes mainly enriched in immune response and down-regulated genes mainly enriched in hair growth cycle and epidermal development. The study identified potential key proteins in MAGA and suggested that continuous monitoring of immune and inflammatory responses, hair growth cycle, and epidermis development can help develop more reliable MAGA treatment regimens. However, the study was limited to public databases, and further research is needed for experimental and clinical validation.

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