Potential of Hair Follicle Stem Cell-Derived Exosomes Carrying miR-181a-5p to Promote the Telogen-to-Anagen Stage

This review highlights that exosome-based therapies show promise for hair regeneration by modulating signaling pathways and enhancing hair follicle regeneration; however, further clinical research is needed due to variability in methods and limited clinical studies.

This study found that exosomes derived from mesenchymal stem cells primed with rapamycin significantly enhanced hair regrowth, hair density, and hair follicle development in depilation-induced mice compared to controls, suggesting a potential therapeutic approach for hair loss.

In this study, patients with androgenetic alopecia experiencing stress had higher cortisol levels and altered neurotrophic factors compared to non-stressed patients, which correlated with more severe hair loss progression even after minoxidil treatment.

This review summarizes recent advancements in using exosomes for promoting hair growth, finding that exosomes from various cells, like dermal papilla and mesenchymal stem cells, show promise as a potential new treatment route for alopecia.

This review examines the mechanisms of hair follicle development and regeneration, discussing current hair loss treatments and emerging therapies like low-level laser therapy and stem cell therapy, which the authors suggest show promise in managing hair loss.

This study found that finasteride and minoxidil act as hormone disruptors in mice, with finasteride having a more significant association with reproductive injuries, such as damage to the epididymis and reduced semen volume.

This study using human and animal models found that adipose-derived stem cell exosomes promoted hair growth and counteracted dihydrotestosterone's inhibitory effects, suggesting potential therapeutic applications for androgenetic alopecia.

In this study, researchers identified key miRNAs and target genes involved in hair follicle development in Merino sheep, providing insights that could aid in improving sheep breeding for wool quality.

This study found that human mesenchymal stem cell-derived extracellular vesicles promote the proliferation and migration of hair follicle cells and increase hair shaft elongation in cultured human hair follicles.

This study found that exosomal miR-181a-5p promotes hair follicle growth and development in vitro by activating the Wnt/β-catenin signaling pathway and suppressing hair follicle stem cell apoptosis.

This study observed that exosomes from adipose-derived stem cells promoted hair growth by enhancing dermal papilla cell proliferation and activating signaling pathways, suggesting potential for treating immune-mediated alopecia.

This study reviewed data from 2,896 hair transplant patients over 10 years, identifying sterile folliculitis, vasovagal shock, facial edema, and other minor complications, with no life-threatening issues reported. Detailed counseling and thorough medical history assessments are recommended to minimize risks.

This study found that adipose-derived stem cell exosomes promoted hair follicle regeneration in mice, resulting in a higher number of regenerated hairs and follicles compared to the control group.

This study reviewed the literature on low-dose oral minoxidil as a primary treatment for various hair loss disorders, concluding that it is a successful and well-tolerated alternative to topical minoxidil for patients with poor adherence to other therapies.

This review explores how epidermal stem cells contribute to the development and maintenance of various skin structures, and highlights specific markers and proteins associated with these cells, but reports no new clinical results.

This article reviews the classification, diagnosis, and management of hair disorders, emphasizing the role of trichoscopy and early diagnosis for effective treatment but reports no new clinical findings.

This review discusses how inflammation influences hair follicle stem cell activities like wound healing and follicle cycling and suggests a potential link between inflammation, stem cell activation, and programmed cell death.

This review discusses strategies to regenerate human hair follicles using stem cells and reports no new experimental results; the authors note existing challenges and the potential of hiPSCs for future applications.

This study found that treatment with mesenchymal stem cell extracellular vesicles enhanced hair growth in mice and stimulated dermal papilla cell activity and growth factor production in vitro.

This article discusses the challenges and possible solutions in hair restoration surgery, focusing on donor hair availability, hair survival, and concealing surgical evidence, and reports no new clinical results.

This study found that IGF-1 injections increased hair follicle number and growth phase duration in wild-type mice, suggesting potential for baldness treatment.

This study developed a 3D engineered hair follicle model that mimics the native hair bulb and may aid in drug screening for hair growth therapies.

This review discusses the evolution and current practices of Follicular Unit Extraction (FUE) in hair restoration surgery, reporting comparable patient outcomes to Follicular Unit Transplantation (FUT), though noting controversies in its adoption.

This study found that estrogen can cause reversible suppression of the hair cycle by inducing premature catagen and maintaining the telogen phase without damaging the hair follicle stem cell niche or the signature gene expressions of dermal papilla cells.

Hair color production is closely linked to the active growth phase of hair in mice and may also influence hair growth itself.