4 citations
,
August 2023 in “Nature Communications” In this study, researchers observed that the combination of hair progenitors and their micro-niche changes every three days in mouse zigzag hair, and disruptions in specific genes affected this rhythm, highlighting the importance of this periodic change for normal hair morphology.
91 citations
,
December 2019 in “The EMBO Journal” This study found that the E3 ligases NEDD4 and NEDD4L regulate intestinal stem cell priming by degrading the LGR5 receptor, and their loss leads to increased Wnt activation and crypt proliferation, which in turn accelerates intestinal tumor progression in mice.
76 citations
,
May 2011 in “Cell death and differentiation” This study found that the enzyme A20 helps regulate EDAR-induced NF-κB signaling in mice, preventing ectodermal abnormalities like disheveled hair and assuring proper skin and appendage development.
46 citations
,
August 2022 in “Animals” This study identified key genes and miRNAs involved in feather morphogenesis in Zhedong White geese, highlighting a negative correlation between FOXO3 and miR-144-y.
This research investigated the role of EphA1 in embryonic and adult tissues, generating mouse models suggesting potential links to skin and colon cancer, sepsis, and post-traumatic injury.
2 citations
,
January 2004 in “Linchuang pifuke zazhi” In a reported case, the use of ZD1839 (Iressa), an EGFR tyrosine kinase inhibitor, resulted in hair changes and acneiform eruptions as cutaneous side effects.
4 citations
,
January 2014 in “Vegetos” This review discusses various medicinal properties and traditional uses of Ziziphus species in human health, emphasizing their potential for new therapeutic applications but reports no new clinical results.
28 citations
,
February 2007 in “Cancer Research” This study found that inhibiting C/EBP transcription factors in mouse skin reduced papilloma formation and caused systemic hair loss, suggesting C/EBP may be a potential therapeutic target.
44 citations
,
March 2016 in “Frontiers in cellular neuroscience” In this study using zebrafish, four bisbenzylisoquinoline derivatives were found to protect hair cells from aminoglycoside-induced damage without reducing antibiotic efficacy, potentially leading to therapies for patients undergoing such treatments.
1 citations
,
July 2023 in “Nature communications” This study found that deleting the Mof gene in mouse skin leads to severe defects in skin cell self-renewal, differentiation, and hair follicle growth, indicating that MOF is crucial for mitochondrial and ciliary gene expression and essential for skin development.
20 citations
,
July 2005 in “Experimental dermatology” This study found that the fuzzy mutation in mice is linked to both structural hair defects and accelerated hair follicle cycling, influencing the regulation of hair cycle phases such as catagen and anagen.
66 citations
,
October 2002 in “Human molecular genetics online/Human molecular genetics” This study found that a nonsense mutation in the Cst6 gene of mice leads to severe skin and hair abnormalities, suggesting that cystatin M/E is crucial for epidermal function and viability.
16 citations
,
June 2015 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that DHHC13 is crucial for hair anchoring and skin barrier function, with its deficiency in Zdhhc13(skc4) mice leading to cyclic alopecia and skin abnormalities due to cornifelin deficiencies.
53 citations
,
August 2010 in “Molecular Carcinogenesis” This review discusses the role of the Slug transcription factor in various epidermal functions and its distinction from the related Snail factor, without presenting new research findings.
7 citations
,
July 2025 in “Nature Communications” In this study using mice, researchers found that the Piezo1 channel regulates metabolic changes and immune cell infiltration during skin growth under tension, with altered expression of glycolysis-related genes and increased macrophage activity observed in stretched skin.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” In this study, researchers found that the loss of SETDB1 in epidermal keratinocytes led to altered chromatin states, increased ERV expression, and activation of immune responses, while inhibiting these effects with certain antiviral drugs reduced skin inflammation and hair loss in a mouse model.
6 citations
,
July 1980 in “PubMed” This study found higher mean zinc levels in the hair of cystic fibrosis patients with growth retardation compared to those with normal growth.
19 citations
,
November 2022 in “Antioxidants” In this study, ginger peel polysaccharides modified with zinc reduced inflammation in zebrafish by altering cytokine expression, suggesting potential for treating chronic inflammation-related diseases.
4 citations
,
December 2022 in “International Journal of Molecular Sciences” This review discusses the role of zinc and its transporters in skin health and disorders, providing an overview without presenting new clinical results.
April 2018 in “Journal of Investigative Dermatology” In this study, researchers identified CENPV as a new CYLD interacting partner that localizes to primary cilia and regulates acetylated tubulin levels, offering insights into the pathogenesis of skin appendage tumors.
April 2023 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that deleting Ube2n in adult mouse skin leads to inflammation and other skin changes, and identifies IRAK1/4 as potential treatment targets for inflammatory skin disorders.
60 citations
,
October 2005 in “Experimental Dermatology” This study found that high-dose oral zinc significantly influences hair growth in mice, showing both inhibition and promotion effects depending on the timing and duration of administration.
4 citations
,
July 2021 in “bioRxiv (Cold Spring Harbor Laboratory)” This study suggests that BLMP-1 is important for timely molting and oscillatory gene expression in C. elegans, indicating a potentially conserved mechanism for rhythmic skin regeneration.
April 2019 in “Journal of Investigative Dermatology” This study found that BRG1 is crucial for keratinocyte migration during skin wound healing, as its suppression impairs wound closure by inhibiting migration without affecting cell proliferation or apoptosis.
5 citations
,
August 2013 in “Epilepsy & Behavior” 111 citations
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February 2017 in “Antiviral research” In this study, researchers discovered that several compounds, including brequinar and 6-azauridine, exhibit significant anti-Zika virus activity using a high-throughput screen assay.
1 citations
,
July 2025 in “Advanced Materials” This study reports on a zinc-coordinated tri-enzyme nanogel system (Zn@nGSC) that mimics natural enzymatic processes to enhance enzymatic activity and cascade efficiency, showing potential in wound healing, hyperglycemia treatment, and antibacterial effects in a murine model of post-pancreatectomy.
57 citations
,
January 2013 in “International Journal of Medical Sciences” This study reports that Lef1 plays a crucial role in promoting bulge stem cell differentiation towards hair fate by activating β-catenin and downstream signaling pathways during hair follicle development.
15 citations
,
May 2014 in “Journal of dermatology” This review suggests the existence of a new syndrome characterized by keratosis pilaris, ulerythema ophryogenes, and monosomy 18p, emphasizing its potential utility in diagnosing monosomy 18p.
This study found that extracellular Granzyme B contributes to skin aging and impaired healing in ApoE knockout mice by degrading essential extracellular matrix components like decorin and fibronectin.