CENPV Is a Novel CYLD-Interacting Molecule Regulating Ciliary Acetylated Tubulin

Five years ago, a study identified the centromeric protein V (CENPV) as a new interacting partner of CYLD, a deubiquitinase with tumor suppressor function. The research showed that CYLD deubiquitinates CENPV and that part of the CENPV pool colocalizes with CYLD to the ciliary base and with acetylated tubulin to the ciliary axoneme, where it regulates the ciliary levels of acetylated tubulin. The study also found that trichoepithelioma and cylindroma, skin appendage tumors, are highly cilitated tumors, and that CENPV is overexpressed in trichoepithelioma but not in cylindroma. This interaction of CYLD with CENPV, a molecule ubiquitinated in higher organisms but not in mice, could explain why CYLD knockout mice do not reproduce a human phenotype. The results supported the idea that centromeric proteins have dual functions in mitosis and ciliogenesis.