Inhibition of CCAAT/Enhancer Binding Protein Family DNA Binding in Mouse Epidermis Prevents and Regresses Papillomas
February 2007
in “
Cancer Research
”
TLDR Blocking certain proteins in mouse skin can reduce and shrink skin tumors.
The study investigated the role of the CCAAT/Enhancer Binding Protein (C/EBP) family in the development of papillomas in mouse epidermis. Researchers found that inhibiting the DNA binding activity of the C/EBP family in the epidermis of mice not only prevented the formation of papillomas but also led to the regression of existing papillomas. This suggested that the C/EBP family played a crucial role in the development and maintenance of papillomas, indicating potential therapeutic targets for preventing and treating such skin lesions.
