TLDR AP-1 controls tumor cell type by affecting key signaling pathways.
The study explored the role of Activator Protein-1 (AP-1) in regulating tumor cell identity in mice, particularly the conversion between squamous papillomas and sebaceous adenomas. By using transgenic mice expressing A-FOS, an inhibitor of AP-1, researchers found that inhibiting AP-1 activity led to the development of sebaceous adenomas instead of typical squamous lesions during skin carcinogenesis. Reactivating AP-1 reversed this process, indicating that AP-1 was crucial for maintaining squamous tumor cell identity. The study also highlighted the involvement of β-catenin and wnt signaling pathways, suggesting that AP-1 activity influenced tumor lineage identity and malignant progression.
26 citations
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June 2003 in “PubMed” Alpha-difluoromethylornithine prevents cancer in mice but causes hair loss.
297 citations
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January 2002 in “Development” Overexpression of ΔNLef1 in mouse skin leads to hair loss, cysts, and skin tumors.
215 citations
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November 2000 in “Journal of Investigative Dermatology” The system allows precise control of gene expression in mouse skin, useful for studying skin biology.
33 citations
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March 1994 in “PubMed” High ODC and low K1 and K10 may indicate early skin tumors in mice.
Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.
Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.
16 citations
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July 2012 in “Current pharmaceutical biotechnology” New treatments for skin conditions related to the sebaceous gland are being developed based on current research.
13 citations
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September 2019 in “EBioMedicine” sPLA2-IIA increases growth in hair follicle stem cells and cancer cells, suggesting it could be targeted for hair growth and cancer treatment.
17 citations
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December 2015 in “International Journal of Cosmetic Science” Visible light can improve skin disorders and hair loss, but more research is needed to understand long-term effects.
