Granzyme B in Skin Aging, Injury and Repair

The study investigated the role of Granzyme B (GzmB) in skin aging and wound healing using ApoE knockout (ApoE-KO) mice, which displayed signs of premature aging and impaired healing when fed a high-fat diet. The research found that GzmB contributed to skin aging and impaired healing by degrading extracellular matrix (ECM) components like decorin and fibronectin, leading to collagen disorganization and delayed wound closure. GzmB/ApoE double knockout (DKO) mice were protected from these effects, showing improved skin condition and wound healing. The findings suggested that GzmB played a significant role in ECM remodeling and skin aging in the ApoE-KO mouse model.