Granzyme B in Skin Aging, Injury and Repair

The study explored the role of Granzyme B (GzmB) in skin aging, injury, and repair, particularly in the context of ApoE knockout (ApoE-KO) mice fed a high-fat diet. These mice exhibited signs of premature skin aging, such as thinning and collagen disorganization, along with impaired wound healing. The research found that GzmB contributed to these effects by degrading extracellular matrix components like decorin and fibronectin. However, GzmB/ApoE double knockout (DKO) mice were protected from these aging signs and showed improved wound healing, indicating that GzmB played a significant role in extracellular matrix remodeling and skin aging in ApoE-KO mice.