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Stem cells are in deep skin layers, while differentiating cells are in shallow layers.

This study found that injections of extracellular vesicles derived from mesenchymal stem cells improved hair growth in over 50% of female and nearly 80% of male patients after six months.

In this study, blue light-irradiated nanovesicles derived from human adipose-derived stem cells enhanced dermal fibroblast proliferation and extracellular matrix synthesis, improving skin maintenance and hair follicle regeneration, suggesting a novel therapeutic strategy for skin and hair disorders.

This study found that extracellular vesicles from erythrocytes may promote hair regeneration in patients with androgenic alopecia by transferring components that upregulate Wnt/β-catenin signaling and are involved in the formation of the skin's outer barrier.

This study found that AtT-20 pituitary cells with higher cAMP-dependent kinase activity had larger calcium currents and significantly increased beta-endorphin release compared to cells with lower kinase activity.

This review discusses the therapeutic potential and challenges of using extracellular vesicles derived from mesenchymal stem cells, concluding that they may have a comparable therapeutic potential to the original cells despite current challenges in their application and production.

This study found that cultured dermal papilla cells can induce hair follicle regeneration and sustain hair growth both in vivo and in vitro, with their effectiveness linked to specific protein expression levels.

This study proposes a two-step method that may enhance the generation of stem-like epidermal cells with superior proliferation and differentiation potential for skin regeneration.

This scoping review explores devices that mechanically process lipoaspirate for cell-based therapies but finds insufficient evidence to determine their clinical effectiveness due to lack of standardization and data variability.

This study successfully established a functionally stable immortalized sheep granulosa cell line (GCs-SV40T-GFP) that can passaged up to 50 generations, maintaining morphological stability and estradiol secretion, offering a valuable model for research into animal reproductive function and hormone regulation.

This study found that knocking out vinculin in mouse skin disrupts bulge stem cell quiescence by impairing force generation and mechanical stability of adherens junctions.

Repigmentation in vitiligo may come from melanocyte stem cells in the skin.

In this study, implantable vascularized engineered thrombi using autologous whole blood improved skin wound healing in rats by promoting robust microcapillary networks and accelerating healing processes.

This special issue reviews advancements in engineering cell microenvironments for tissue engineering, highlighting various studies on interventions like silk fibroin and platelet-rich plasma, but presents no new empirical findings.

This study found that perifollicular vascularization around the dermal papilla adjusts dynamically to physiological changes, with minoxidil enhancing vessel mobilization and aging processes inhibiting it, highlighting potential targets for treating hair loss and skin aging.

This study found that using layer-by-layer encapsulation techniques on dermal papilla cells can support their function and may help treat hair loss when used in conjunction with freshly isolated epidermal cells.

This study found that human dermal stem/progenitor cells demonstrated greater proliferation and differentiation potential than hair follicle dermal papilla cells, which showed increased expression of hair regeneration markers.

This article reviewed a study suggesting that CCN1 secreted by human adipose-derived stem cells may enhance wound healing, although the authors note limitations such as small sample size and incomplete evaluation of wound healing processes.

This study suggests that alkaline phosphatase-regulated expression of CCL5 contributes to the trichogenicity of human dermal papilla spheres.

This study found that modifying adipose-derived stem cells to overexpress the adhesion protein JAM-A increased the adhesion and resilience of dermal papilla cells in the context of androgenic alopecia, potentially facilitating hair regrowth despite challenges such as damage from dihydrotestosterone and macrophages.

This review examines the role of epidermal stem cells in wound healing, discussing their characteristics and mechanisms, but does not report new clinical results.

This study demonstrates that neural stem cells in the adult vertebrate brain coordinate their division decisions using delayed local feedback mechanisms, involving Notch-mediated inhibition and dispersion effects, to maintain population homeostasis.

This review discusses methods for generating induced pluripotent stem cells and highlights their recent applications in studying and treating COVID-19, but it reports no new experimental results.

In this study, nondermal-derived CD34+ cells from adult peripheral blood were found to enhance wound healing and contribute to hair follicle neogenesis and skin regeneration.

This study found that using 3D cultures and fetal tissue extracts significantly improved the outcomes of stem cell treatments for regenerative medicine, including hair follicle formation and chronic wound healing.

This study identified a comprehensive global landscape of stemness-related gene clusters in adipose-derived mesenchymal stem cells, revealing that stemness was highest in cells from young donors and lowest in those from elderly donors.

This study found that expanding hair follicle keratinocytes with a fibroblast feeder followed by short-term coculture with dermal papilla cells could restore their ability to form new hair follicles.

This review discusses recent advances in using extracellular vesicles as a potential treatment for alopecia and highlights ongoing challenges in their clinical application and mass production; no new clinical results are reported.

This review found that vesicle-based therapies, including mammalian MSC-derived and plant-derived vesicles, consistently promote wound healing in preclinical models of thermal injury and may offer a safer alternative to live cell transplants.