The Composition of Cell-Based Therapies Obtained From Point-of-Care Devices/Systems Which Mechanically Dissociate Lipoaspirate: A Scoping Review of the Literature

This scoping review examined the composition and clinical applications of cell-based therapies derived from point-of-care devices that mechanically dissociate lipoaspirate. It identified 13 unique devices and highlighted differences in cell surface markers and cell populations, such as CD146, CD34, and CD31, across different devices. The review found that these devices generally achieved higher cell concentrations and viabilities compared to conventional methods, but noted significant variability due to a lack of standardization. Clinical outcomes were assessed in a few studies, showing positive results in applications like orthopaedic and general surgery, but the evidence was mostly low-level. The review emphasized the need for better understanding and reporting of cellular components to evaluate the efficacy of these therapies.