Comparative Analysis of Stemness Between Dermal Papilla Cells and Human Dermal Stem/Progenitor Cells

April 2025 in “ Cellular and Molecular Biology ”

Joong Hyun Shim

hair follicle dermal papilla cells human dermal stem/progenitor cells adult stem cells tissue regeneration SOX2 S100β protein kinase phosphorylation ERK1/2 c-JUN CREB YES GSK3α/β dermal fibroblasts HFDPCs hDSPCs ASCs

TLDR Human dermal stem/progenitor cells can divide and differentiate more than hair follicle dermal papilla cells.

This study compares the properties of hair follicle dermal papilla cells (HFDPCs) and human dermal stem/progenitor cells (hDSPCs), both types of adult stem cells (ASCs) with potential for tissue regeneration. hDSPCs exhibit greater cell division and differentiation capacity into adipocytes, chondrocytes, and osteoblasts than HFDPCs. Conversely, HFDPCs show higher expression of markers related to hair regeneration, such as SOX2 and S100β. Protein kinase assays reveal significant changes in the phosphorylation of ERK1/2, c-JUN, CREB, YES, and GSK3α/β in both cell types compared to dermal fibroblasts, which may explain their differing properties. These findings suggest that the unique characteristics of each ASC type could influence their therapeutic applications.

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