Mechanical Instability of Adherens Junctions Overrides Intrinsic Quiescence of Hair Follicle Stem Cells

    January 2020 in “ bioRxiv (Cold Spring Harbor Laboratory) ”
    Ritusree Biswas, Avinanda Banerjee, Sergio Lembo … S. Raghavan

    Preprint — not peer reviewed. This was posted to a preprint server or data repository. It has not been through a journal's review process, and its findings may change or not hold up.

    Studysummary This study found that knocking out vinculin in mouse skin disrupts bulge stem cell quiescence by impairing force generation and mechanical stability of adherens junctions.
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    Research cited in this study 10

    1. Signaling Involved in Hair Follicle Morphogenesis and Development International Journal of Molecular Sciences · 2014
    2. Lrig1 Expression Defines a Distinct Multipotent Stem Cell Population in Mammalian Epidermis Cell stem cell · 2009
    3. Lgr5 Marks Cycling, Yet Long-Lived, Hair Follicle Stem Cells Nature Genetics · 2008
    4. Defining BMP Functions in the Hair Follicle by Conditional Ablation of BMP Receptor IA The Journal of Cell Biology · 2003
    5. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003
    6. Enrichment for Living Murine Keratinocytes from the Hair Follicle Bulge with the Cell Surface Marker CD34 Journal of Investigative Dermatology · 2003
    7. Involvement of Follicular Stem Cells in Forming Not Only the Follicle but Also the Epidermis Cell · 2000
    8. Multiple Roles for Activated LEF/TCF Transcription Complexes During Hair Follicle Development and Differentiation Development · 1999
    9. Assembly of Hair Keratins in Transfected Epithelial Cells Biochemical and Biophysical Research Communications · 1996
    10. Dermal-Epidermal Interactions in Hair Follicle Development and Cycling Clinics in dermatology · 1988