Assembly of Hair Keratins in Transfected Epithelial Cells

December 1996 in “ Biochemical and Biophysical Research Communications ”

Motomu Manabe, Masayuki Mizoguchi, Masanao Niwa, Arthur P. Bertolino, Kazumi Ishidoh, Eiki Kominami, Hideoki Ogawa

hair keratins mHa1 mHb4 epithelial cells keratin network PtK2 cells rat epidermal keratinocytes keratin cytoskeleton K5/K14 K8/K18

TLDR Mouse hair keratins mHa1 and mHb4 can't form a strong network on their own in cells.

The study investigated the assembly of hair keratins by introducing mouse hair keratin genes mHa1 and mHb4 into two types of epithelial cell lines: PtK2 and rat epidermal keratinocytes. In PtK2 cells, these keratins formed ring-like aggregates around the nucleus, disrupting the endogenous keratin network and causing it to collapse. However, in rat epidermal keratinocytes, mHa1 and mHb4 successfully co-localized with the existing keratin cytoskeleton. The findings indicated that the mHa1/mHb4 pair could not independently form an extensive keratin network, unlike other keratin pairs such as K5/K14 and K8/K18, suggesting differential abilities among keratins to develop cytoplasmic networks.

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research Keratin and Skin Disorders

28 citations , April 1996 in “Cell biology international”

Changes in keratin affect skin health and can lead to skin disorders like blistering diseases and psoriasis.